Introduction: Diabetes is common in Pakistan, with prevalence rates ranged from 7.6 -11%. Diabetics especially type 2 diabetes mellitus have a much higher odds of being vitamin d deficient. Objective: To compare mean decrease in glycated hemoglobin in vitamin D supplementation with placebo in the treatment of type I diabetes mellitus Methodology: This study design was randomized controlled trial carried out at the medicine department Lady Reading Hospital Peshawar for duration of six months after synopsis approval from July 2021 to December 2021. Sixty patients were included in our study. Patients in group A were subjected to routine diabetes therapy plus vitamin D supplementation in a dose of 600000 units per oral every two weeks for 3 months and patients in group B were subjected to only routine diabetes therapy. Data was entered and analyzed by statistical package for social sciences (SPSS) version 20. Results: Base line HbA1C Level among Group A patients was analyzed as Mean was 9.27 and Std. Deviation was 1.58 whereas in group B subjects, the mean HbA1C Level was 9.28 and Std. Deviation was 1.59. Post HbA1C Level in Group A patients was analyzed as Mean was 7.29 and Std. Deviation was 1.40 whereas in group B subjects, the post mean HbA1C Level was 7.51 and Std. Deviation was 1.73 Conclusion: Our study concludes that supplementation of Vitamin D could improve Vitamin D level in blood but have no significant association with the reduction of HbA1c level in patients with Type II diabetes mellitus. Keywords: Glycated hemoglobin; Vitamin D supplementation, Type II diabetes mellitus
Introduction: The purpose of this research was to examine how a very low-calorie ketogenic diet affected body composition and metabolic rate in overweight and obese people. Method: A 12-week weight loss program using a ketogenic diet that had only a few hundred calories per day was offered to 80 participants at the Hayatabad Medical Complex in Peshawar. Participants consumed 800-1000 calories each day and were instructed to maintain a state of ketosis. Data on body composition, metabolic rate, and appetite hormones were collected at baseline and after the intervention. Results: The study's findings demonstrated that a ketogenic diet consisting of extremely few calories helped people lose a considerable amount of weight and improved their body composition and metabolic rate. Participants' weight, fat percentage, and circumference of the waist all decreased, as well as an increase in lean body mass. The metabolic rate of the participants increased, suggesting that the ketogenic diet may help with weight reduction and metabolic health. Conclusion: This research shows that an exceedingly low-calorie ketogenic diet may help those who are overweight or obese, especially those who have insulin resistance, lose weight.
Background: Polycystic Ovary Syndrome (PCOS) is among the most prevalent endocrine conditions that affects women of reproductive age. Genetics, obesity, birth weight and insulin resistance are some of the inherited and environmental variables that have been associated to the etiology of PCOS. Objective: To study the frequency of insulin resistance and their association with BMI in polycyclic ovarian syndrome Methods: This study was cross-sectional, carried out at the physiology department Northwest School of Medicine Peshawar. The study duration was six months from January 2022 to June 2022. After an overnight fast (12–14 hours), 2.5ml of venous blood was drawn into a sodium fluoride and EDTA tube. This blood was used to measure the fasting plasma glucose (FPG). Insulin levels were determined by concurrently drawing 2.5 ml of venous blood. A separate proforma was used to input all the data. On SPSS 23, all data were entered and examined. Results: In our study, totally 180 patients participated. The mean age with ±SD was 26±4.23 years. The overall frequency of insulin resistance observed in our study was 117 (65%). A statistical significant association was observed between BMI of ≥25 and insulin resistance (p=0.021). Conclusions: Our study concludes that the frequency of insulin resistance in polycyclic ovarian syndrome is high. A statistical significant association was observed between BMI of ≥25 and insulin resistance in our study. Keywords: Insulin resistance; BMI, polycyclic ovarian syndrome
Objectives: To determine whether serum vitamin D levels are correlated with serum levels of alkaline phosphatase or not? Study Design: Case control cross sectional study. Setting: Gastroenterology unit of private teaching hospital in Peshawar. Period: From November 2015-Januaray 2016. Material and Methods: 100 participants meeting the criteria were included in the study. Fifty clinically normal young adults and fifty were non cirrhotic chronic hepatitis C patients were included in the study. Venous blood samples were taken from all the study participants and serum vitamin D levels were determined by Electro-chemiluminescence binding assay (ECLIA) and serum alkaline phosphatase was determined by Photometric Kinetics. Results: patients were divided into two groups on the basis of gender i.e.25 males and 25 females. A correlation between vitamin D and alkaline phosphatase was determined. Alkaline phosphatase was raised in the non cirrhotic chronic hepatitis C patients. Pearson correlation was applied to find out the relation between vitamin D levels and alkaline phosphatase in the two groups which had a significant relationship with a p-value of 0.01. A positive correlation between alkaline phosphatase and parathyroid hormone was found with a p value of <0.0001. Conclusion: In our study alkaline phosphate was considerably increased in chronic hepatitis C patients who might be due to underlying liver disease. In chronic liver disease the hepatocytes swell up and due to damage to the liver parenchyma the level of alkaline phosphatase increases.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.