Introduction: Frequent contribution of blood can cause iron exhaustion in blood donors along with the problems related to it. Curtailing the proportion of iron reduction among blood donors is a crucial plan for boosting donor’s well-being. Aim & objectives: The aim of this analysis is to determine iron stocks by measuring serum ferritin in pre-donation male blood donors along with their relation with the hemoglobin concentration and frequency of blood donations. Study design: Cross-sectional study. Place and duration: Pathology (immunohematology) department and blood bank of University of Child Health Sciences, The Children Hospital Lahore from Aug 2021 to July 2022 Material and Methods: A total of 350 serum samples were processed to determine hemoglobin and serum ferritin concentrations. The study involved was performed on healthy blood donors. The method used was chemiluminescence for the simultaneous measurement of serum ferritin. Results: An aggregate of 350 serums were collected from the contributors in blood bank. Among them, 154 were the first-time donor and 196 were the frequent donors; the serum ferritin was markedly reduced in constant contributors. The mean value 105ng/mL was found in infrequent donors and 79.35ng/mL was found in frequent donors. There was no notable variance in hemoglobin of newbie and regular blood givers. However, a momentous variation in the pervasiveness of iron depletion between first‑time and regular donors is found. Conclusion: Blood donation has a noteworthy impact on iron stores and is one of the most important factors for iron shortage in contributors, specifically in those who donate blood again and again. Serum ferritin measurement ought to be incorporated in the blood donor preference especially in the evaluation of consistent blood givers to assure enough iron pools in the donor community in order to sustain a pertinent potential donor.
Objective: To scrutinize extra gastric associations of Helicobacter Pylori (H Pylori) infection with disorders those come under hematology domain. Design: Descriptive cross sectional Place and duration: Histopathology and hematology department of Bakhtawar Amin Medical & Dental College and Trust hospital, Multan from Jan 2021 to Dec 2021 Material and methods: Complete blood count (CBC) and peripheral blood microscopic examination were done in every histopathologically approved H Pylori positive patient to record hemoglobin (Hb %), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) and platelet count. Serum Iron, serum ferritin, serum Vitamin B 12 and folic acid levels were done in suspected cases only. Patients with low platelet count were checked in detail for immune thrombocytopenic purpura (ITP). The CBC samples were taken twice once at the time of delivery of histopathology report and second time after treatment of H Pylori infection to check reversal of counts and peripheral blood changes for authentication of H Pylori association with these blood changes. The test results along with the essential details like age, gender, nutritional history, previous medical history esp. related to these disorders and menstrual history in females were recorded on excel sheet and the proportions of all the variables were calculated to extract appropriate tables and figures. Results: Out of total 132 gastric biopsies received in Histopathology department Helicobacter Pylori prevalence noted to be 78.8 %. Eighty three (79.8 %) out of 104 H Pylori positive cases revealed extra gastric hematological manifestations and in 59 (56.7 %) of these patients the blood indices along with peripheral blood picture returned to normal on H Pylori eradication. Conclusion: A large number of H Pylori positive patients displayed hematological manifestations that reverted to normal on taking H Pylori treatment. H Pylori should be kept in mind especially dealing cases of unexplained iron deficiency, vitamin B12 anemia and Immune thrombocytopenia. Keywords: Helicobacter Pylori infection, iron deficiency anemia, histopathology, platelets, vitamin B 12 deficiency anemia, serology
Background: Typhoid fever is an acute systemic infection caused by Salmonella Enterica Serovar Typhi. Organism is transmitted by fecal-oral route. Aim: To determine frequency of various histopathological & hematological manifestations of typhoid fever in pediatric age group. Study design: Cross-sectional survey. Methodology: Complete blood count, pro-thrombin time and activated partial thromboplastin time were performed on the patients (n=140) to find out various hematological manifestations. Histopathological findings of patients undergoing colonoscopy and biopsy due to gastrointestinal presentations were also noted. Results: Present study had 65% males with 35% females. Almost 65.7% cases presented with anemia. Around 50.7% patients had leucopenia while eosinopenia was 67.1%. Cases (39.3%) presented with prolonged activated partial thromboplastin time while 32.1% cases had prolonged pro-thrombin time. Among histopathological manifestation, 3(2.14%) presented with Typhoid colitis/enteritis, 2(1.43%) with gastrointestinal bleeding due to ulcers and only 1(0.71%) with peritonitis. Conclusion: It was concluded that most common haematological manifestation in typhoid fever was eosinopenia which was most frequently found in coexistence with thrombocytopenia. However, histopathological abdominal complications were quite rare but could be dreadful and should be kept in mind. Keywords: Typhoid Fever, Hematological, Histopathological Manifestations, Abdominal complications and Children.
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