Two cases are presented with coronavirus disease 19 (COVID-19)-related hiccups: one during initial presentation and one 10 days after COVID-19 diagnosis. Hiccups in both patients were resistant to treatment and responded only to chlorpromazine. COVID-19 patients may present with hiccups and also may have hiccups after treatment. Resistant hiccups without any underlying disease other than COVID-19 should be considered in association with COVID-19 and may respond well to chlorpromazine.
Introduction:Lung cancer is most common cause of cancer-related mortality worldwide. Non-small-cell lung carcinoma (NSCLC) is disease with very low 5-year relative survival rate. For patients with non-small cell lung cancer, roles of current treatments are to prolong survival time and to improve quality of life.Aim:The aim of the work was to compare values of Glasgow Prognostic Score (GPS) before application of the chemotherapy medication with response to chemotherapy and toxic side effects associated with chemotherapy in patients treated with cisplatin-etopozid (PE) and cisplatin-gemcitabin (PG) in stages IIIb and IV of NSCLC. Testing role of Glasgow Prognostic Score as a possible predictor of response to therapy and toxic side effects of chemotherapeutic protocol was another aim of this work.Patients and methods:This prospective study included 60 patients in stages IIIb or IV of NSCLC, with ECOG ≤ 2. The patients were divided in two groups. First group contained 30 patients treated with chemotherapeutic protocol using cisplatin-etopozid (PE), and the same number of patients in the second group were treated with cisplatin-gemcitabin (PG).Results:Glasgow Prognostic Score (GPS) evaluation before the chemotherapy inclusion showed values of 1 (43.30:53.30), then 2 (40.00:36.70) and the lowest 0 (16.70:10.00) which supports the pathological values of GPS in developed lung cancer, i.e. most patients had pathological GPS value in both protocols (83.30:90.00). Monitoring of toxic side effects and response to chemotherapy was done after each cycle of treatment.Discussion:Results of this study revealed importance of GPS in selection of patients for treatment with chemotherapy. Patients with lower values of GPS treated using PE chemotherapeutic protocol had weaker response to therapy.Conclusion:Coefficient of correlation for therapy response in both chemotherapeutic protocol, compared with values of GPS before treatment, were not statistically significant, therefore GPS cannot be considered as a predictor of therapeutic on chemotherapy.
Introduction: Lung cancer is most common cause of cancer-related mortality worldwide. Non-small-cell lung carcinoma (NSCLC) is disease with very the pathological values of GPS in developed lung cancer, i.e. most patients had pathological GPS value in both protocols (83.30:90.00). Monitoring of toxic side effects and response to chemotherapy was done after each cycle of treatment. Discussion: Results of this study revealed importance of GPS in selection of patients for treatment with chemotherapy. Patients with lower values of GPS treated using PE chemotherapeutic protocol had weaker response to therapy. Conclusion: Coefficient of correlation for therapy response in both chemotherapeutic protocol, compared with values of GPS before treatment, were not statistically significant, therefore GPS cannot be considered as a predictor of therapeutic on chemotherapy.
Early stage of the disease looks like abscess and cellulitis. This benign image is the most important reason behind late diagnosis. But, cellulitis can be a very dangerous disease because of its tendency to spread the infection through blood or lymph and deeper pe-ABSTRACT Deep neck infections still remain one of the important causes of morbidity, although their prevalence has been diminished with modern antimicrobal therapy. The target of the retrospective is to demonstrate our experience in the treatment of serious cases of deep neck infections (phlegmons) and to identify the predictors of a possibly poor outcome. This retrospective study comprised 44 patients with neck phlegmons, who were treated at the ENT Clinic, during 2000-2016. The study included the etiology, predisposing factors, causative microbiological organisms, and the clinical outcomes associated with the mortality. During investigated time period, 44 patients with deep neck infections (phlegmons) were noted. The median age of the patients was 45.9 years (range, 14-81), and study population included 26 males (59%). The median hospital stay was 22.5 days (from 3-80 days). Staphylococcus aureus was the most commonly isolated bacteria. Death was noted in 10 patients (22.7%). Timely diagnosis together with aggresive surgical treatment and appropriate antibacterial therapy were the key to sucess in the treatment of the patients with deep neck infections. The factors associated with poor prognosis in our patients included tonsillar disease, diabetes mellitus, mediastinitis, age above 65 years.
Objective:The aim of the study was to present experience of performed tracheotomies during the Covid19 pandemic and to outline the adjustments made to the procedure for security reasons. Materials and Methods:In the retrospective study for the period March 2020 to April 2022 we analyzed the disease history data and surgical findings from all patients in UCC Tuzla who underwent surgical tracheotomy during the COVID-19 pandemic. Results: 52 patients who underwent open surgical tracheotomy after an invasive mechanical ventilation were analyzed in our study. Group A were 32 COVID-19 consecutive patients (22 male, mean age±13.54 years, range 23-76). The tracheotomy was performed approximately on day 12.4 of the intubation (range 4-28). Group B consisted of 22 patients who had not suffered from COVID-19, and their PCR test was negative for SARS-Cov-2 (12 male, mean age 59.4±20.40 years, range 19-87). The tracheotomy was performed approximately on day 10.1 of the intubation (range 2-20). There was a statistically significant difference in mortalities when both groups were compared. The most common complication was diffuse bleeding from soft tissue of the neck in the early post tracheotomy period and local infection in the later period. The most common comorbidities were arterial hypertension and diabetes mellitus. Conclusion: According to our study results, COVID-19 elderly patients who are on Invasive Mechanical Ventilation (IMV) have an uncertain prognosis. Correct timing of the tracheotomy is necessary so as not to further traumatize the patients.
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