Background: Asthma is a chronic inflammatory process that affects the airways of the lung. It has a greater impact on public health. It is a polygenic disease, many factors play a role implicated in triggering its that starts like genetic, environmental, and geographic factors. Genetic studies have focused on the forkhead box O3 (FOXO3a) gene, mainly polymorphism at the specific sites which is thought may contribute to exacerbating the attack and complications of asthma. Methods: The study was designed as a case-control and involved 138 of asthmatic patients and 120 seemingly healthy people used as a control group. The diagnosis was carried out by consultants at a special respiratory center in Babylon governorate. Genotyping of all subjects was done for FOXO3a (rs13217795; C/T) analysis by PCR-RFLP technique. Multinominal regression was used to calculate Odds ratios (ORs) and 95% confidence intervals (CIs) by IBM. SPSS software version 20.0. Results: Analysis of the results that obtained form this work a considerable modification in forms of rs13217795; C/T polymorphism between asthmatic and healthy individuals. elevation in the risk of asmathic patient was seen in T allele of FOXO3a gene (odds ratio of 2.0313, 95% CI: 1.5493 - 2.6631, P<0.0001).
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