In view of high incidence of mortality with Ethylene dibromide poisoning, a retrospective study was conducted, with objectives to compare demographic, toxicological & clinical outcome in patients treated conservatively and those who underwent therapeutic plasmapheresis. Records of Forty patients from central India region, with ingestion of ethylene dibromide admitted over last six years were reviewed .The majority of patients were less than 30 years (77.5%). Gastrointestinal symptoms (87.5%) were predominant at presentation. Amongst biochemical parameters hepatotoxicity was seen in 26 (65%), cardio toxicity in 19 (47.5%) and renotoxicity was seen in 4 (10%). Fourteen patients (35%) had normal biochemical parameters. Out of 26 patients with hepatotoxicity, 13 were treated conservatively whereas 13 underwent plasmapheresis. In conservative group the mean liver enzymes level were 937.6 I.U./ml (range 96-3717) ,while in plasmapheresis group it was 2587.6 I.U./ml (126-11700). The mortality rate was 5/13(38.4%) in conservatively treated patients as compared to 3/13(23%) in plasmapheresis group. Mean length of hospital stay was 5.4 days (range 2-20 days).Best outcome was when the patient presented to the hospital within six hours of ingestion. Death occurred anywhere between twenty hours and five days. Ethylene dibromide is highly toxic substance with a reported mortality rates as high as 30-60%.In our study we found a 15.4% decrease in mortality in plasmapheresis group as compared to conservative. Thus plasmapheresis may be considered an important treatment modality for ethylene di bromide poisoning.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.