Summary. It appears that women classed as having pre-eclamptic toxaemia are less frequently consanguineous with their husbands than all other mothers and in particular those mothers classed as having pregnancies complicated by chronic hypertensive disease. Search revealed no evidence for possible biases which could have simulated such findings.Further evidence is advanced suggesting that, though pre-eclamptic toxaemia is more common in all types of twin pregnancies than in single births, it is more common where the twins are dizygous than where they are monozygous.It is pointed out that both these findings would be expected if there was a contribution to the aetiology of pre-eclamptic toxaemia by maternal/fetal immunological incompatibility. However, if such a mechanism exists it is not always determined at the same gene locus. (1971) concluded that the proportion of women who had pre-eclamptic toxaemia who were related to their husbands was significantly less than in the other patients.By early 1973, 23 416 mothers with single pregnancies and 271 with twin pregnancies had been studied. Basic information concerning these patients is set out in Table I. Records in respect of 58 of the patients with single pregnancies were incomplete in respect of one or more of the variables presented in subsequent tables, so these forms were ignored and the total in subsequent tables is 23 358.Ten women (none classified as having pre-eclamptic toxaemia) were identified as having been admitted for two pregnancies during the period of the study.
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