No abstract

Four new sesquiterpenes, (8R)-8-bromo-10-epi-beta-snyderol (1), (8S)-8-bromo-beta-snyderol (2), 5-bromo-3-(3'-hydroxy-3'-methylpent-4'-enylidene)-2,4,4-trimethylcyclohexanone (3), and the epoxide 4, have been isolated from the chloroform-methanol extract of Laurencia obtusa, together with the three known compounds alpha-snyderol (5), alpha-snyderol acetate (6), and stigmasterol. The structures of the isolated compounds were elucidated through spectroscopic analyses. Compound 1 showed antimalarial activity, with IC(50) values of 2700 and 4000 ng/mL against the D6 and W2 clones of Plasmodium falciparum, respectively.

The polyunsaturated v3-fatty acids, eicosapentaenoic acid and docosahexaenoic acid, have positive effects against to cardiovascular diseases. This work was carried out to investigate the fatty acid composition of the most popular fish from Turkey (mainly Istanbul area) and their nutritive values. Total lipid amounts and fatty acid compositions of 6 commonly consumed fish species were determined. Analyses of fatty acid methyl esters were performed by capillary gas chromatography. Palmitic acid (C16:0) and oleic acid (C18:1v9) were the predominant saturated and monoenoic fatty acids. The predominant polyunsaturated fatty acids were eicosapentaenoic acid (C20:5v3) and docosahexaenoic acid (C22:6v3). European anchovy and European pilchard are concluded to be good dietary sources of v3-polyunsaturated fatty acids, which are known to reduce the risk of cardiovascular diseases because of their high C20:5v3 and C22:6v3 content.