Türk derm-De ri Has ta lık la rı ve Fren gi Ar şi vi Der gi si, Ga le nos Ya yı ne vi ta ra f›n dan ba s›l m›fl t›r. Turk derm-Arc hi ves of the Tur kish Der ma to logy and Ve ne ro logy, pub lis hed by Ga le nos Pub lis hing. Özetİlaçla ilişkili hipersensitivite sendromu (İİHS), ilaç reaksiyonları arasında en tehlikelilerinden biridir. Sistemik organ tutulumları bu reaksiyonun mortalite ve morbiditesini arttırmaktadır. Lezyonlar en sık makülopapüler döküntü şeklinde ortaya çıkmakla birlikte, lezyon morfolojisi farklılık gösterebilir. Çoğunlukla aromatik antikonvulzanlarla ortaya çıkar. Ancak başka ilaçların da bu ilaç reaksiyonu patogenezinde rol oynayabileceği unutulmamalıdır. Erken tanı tedavide en önemli basamaktır. Burada sulfasalazin ile tetiklenen ve klinik olarak makülopapüler döküntüye eşlik eden püstüler lezyonlarla prezente olan bir İİHS olgusu sunmaktayız. Sum maryDrug-induced hypersensitivity syndrome (DIHS) is one of the most dangerous drug reactions. Mortality and morbidity is increased by consequent systemic organ involvement. Maculopapular eruptions are the most common lesions accompanying DIHS, however, the morphology of skin lesions may vary. The most common cause of DIHS is the use of aromatic anticonvulsant drugs. However, one must not forget that other drugs may also cause DIHS. Early recognition of the condition is the most important step in the treatment. Herein, we present a case of DIHS triggered by sulphasalazine and associated with pustular eruption and maculopapular eruption. (Turkderm 2013; 47: 123-5)
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