Introduction and Objectives: Cardiovascular diseases are the main cause of death in Brazil and in the world, furthermore, affect the quality of life of people affected by these diseases. The objective of this study was to compare the quality of life of women with cardiovascular risk (WCR) and without cardiovascular risk (WTCR). Methods: The G- power software was used to calculate the sample. Cardiovascular risk stratification was performed using the Framingham Risk Score, available in the “ER calculator version 2017”. Quality of life was assessed using the Brazilian version of Short Form Health Survey-36 (SF-36) Questionnaire. Statistical analyzes were performed using SPSS software, version 20. Results: 116 women were stratified into two groups; WCR (n=66) and WTCR (n=50). Mean age, weight, body mass index (BMI), total cholesterol (TC), high density lipoprotein cholesterol (HDL-c), triglycerides (TG), low density lipoprotein cholesterol (LDL-c), systolic blood pressure (SBP) and glycemia differed significantly between groups. Among the domains of quality of life, pain (p<0.02) and limitation due to physical aspects (RP, p<0.01) differed significantly. The cardiovascular risk factors (CRF), age and BMI influenced the domain social aspects, TG in physical capacity and BMI in the general health status of women with risk. LDL-c and CT influenced the emotional aspects of WTCR women. Conclusions: The scores of the quality-of-life domains of WCR women are lower (except for SF) than those of WTCR women, differing significantly in pain and limitation due to physical aspects.
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