Assess short-term real-world outcomes in neovascular aged-related macular degeneration (nAMD) treated with novel faricimab. MethodsRetrospective case series of nine patients with nAMD (11 eyes) treated with faricimab between May and November 2022. Treatment-naïve patients and non-naïve patients underwent best corrected visual acuity (BCVA), optical coherence tomography (OCT) DRI OCT-1 Triton (Topcon Corp, Tokyo, Japan), ultrawide eld (UWF) and fundus auto uorescence (FAF) (California Optomap, Optos plc, Dunfermline, Scotland, UK). Previous treatment intervals, number of intravitreal injections, sub/intra retinal uid (SRF/IRF), central retinal thickness (CRT) and presence/changes in pigment epithelial detachments (PEDs) were recorded. ResultsMean baseline BCVA and CRT values of patients who switched from other agents were 0.612 and 256.16 µm respectively, with a mean 36-day previous treatment interval. The median number of other previous anti-VEGF intravitreal injections was 8. The mean baseline BVCA and CRT values of the 3 naïve patients were 0.33 and 874.67 µm, respectively. At one month follow-up, mean BCVA improvement was 0.32 and mean CRT reduction was 338.44 µm. A complete resolution of SRF and IRF was observed in 75% and 33.33%, respectively. Drusenoid PED morphology changes were observed in all patients. No drug-related adverse events were observed. ConclusionReal-world outcomes showed improvement in BCVA and anatomic parameters at an early timepoint, demonstrating the e cacy and durability of faricimab in nAMD patients. Larger numbers of patients and longer follow-up are needed to determine whether the loading dose is required in all; what percentage of patients experience an improvement, and whether improvement it is maintained.

Objective: To introduce VFO and SK VFO Test: new, more representative terminology for symptoms of vitreous floaters/opacities (VFO) and new standardized kinetic (SK) anatomical-functional assessment. Materials and Methods: Eight eyes underwent before-after limited vitrectomy (LV): best-corrected visual acuity, low-luminance visual acuity, Minnesota Low Vision Reading Chart near visual acuity in logMAR, contrast sensitivity function (CV1000E), and straylight measurements (SM) (HDA/LDA/C-Quant). SK infrared confocal scanning laser ophthalmoscopy (SK IRcSLO) and swept-source widefield optical coherence tomography (SS-WF-OCT) identified VFO and posterior vitreous detachment (PVD). SK IRcSLO was performed with gaze directed towards the extreme superior, inferior, and lateral directions. Results: Anatomical-functional results after LV improved in 7 eyes (87.5%): objective scatter index (27.34%), disturbance index (47.97%) and C-Quant Log units (2.26%). Pre-LV SK IRcSLO and SS-WFOCT imaging identified dynamic well-defined VFO and PVD status (100%). A residual asymptomatic anterior cortical vitreous-induced shadowing ripple effect was detected post-LV. Conclusions: This is the first objective-standardized test accounting for VFO kinesis and intermittent effect. There is potential for personalizing treatment and establishing best candidates for laser or surgery. [ Ophthalmic Surg Lasers Imaging Retina 2023;54:306–315.]

Purpose Assess short-term real-world outcomes in neovascular aged-related macular degeneration (nAMD) treated with novel faricimab. Methods Retrospective case series of nine patients with nAMD (11 eyes) treated with faricimab between May and November 2022. Treatment-naïve patients and non-naïve patients underwent best corrected visual acuity (BCVA), optical coherence tomography (OCT) DRI OCT-1 Triton (Topcon Corp, Tokyo, Japan), ultra-widefield (UWF) and fundus autofluorescence (FAF) (California Optomap, Optos plc, Dunfermline, Scotland, UK). Previous treatment intervals, number of intravitreal injections, sub/intra retinal fluid (SRF/IRF), central retinal thickness (CRT) and presence/changes in pigment epithelial detachments (PEDs) were recorded. Results Mean baseline BCVA and CRT values of patients who switched from other agents were 0.612 and 256.16 µm respectively, with a mean 36-day previous treatment interval. The median number of other previous anti-VEGF intravitreal injections was 8. The mean baseline BVCA and CRT values of the 3 naïve patients were 0.33 and 874.67 µm, respectively. At one month follow-up, mean BCVA improvement was 0.32 and mean CRT reduction was 338.44 µm. A complete resolution of SRF and IRF was observed in 75% and 33.33%, respectively. Drusenoid PED morphology changes were observed in all patients. No drug-related adverse events were observed. Conclusion Real-world outcomes showed improvement in BCVA and anatomic parameters at an early timepoint, demonstrating the efficacy and durability of faricimab in nAMD patients. Larger numbers of patients and longer follow-up are needed to determine whether the loading dose is required in all; what percentage of patients experience an improvement, and whether improvement it is maintained.

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