A straightforward synthesis of 2Ј-functionalized uridines was developed based on a Cu-catalyzed cycloaddition of 2Ј-azido-2Ј-deoxyuridine and functionalized alkynes. The functions comprise biochemically important groups such as lipids, a fluorescent marker (Cy5 analogue), pentaacetylglucose, lysine and biotin, and are linked to the 2Ј-position of uridine
New functionalized magnetic core-shell nanostructures were developed based on magnetite as magnetic core covered with pyrrole copolymers substituted by α-amino acids. The 3-substituted pyrrole monomers were synthesized by amide formation between an α-amino acid and 4-(1-phenylsulfonyl-(1H-pyrrol-3-yl)-4-oxo-butyric acid. Further, these substituted pyrrole monomers were copolymerized with unsubstituted pyrrole by oxidation with ammonium persulfate in the presence of water based magnetic nanofluids yielding functionalized magnetic core-shell nanostructures. The morphology of these magnetic functionalized polypyrrole core-shell nanoparticles was investigated by TEM and HRTEM, while the molecular structures and magnetic properties were investigated by FTIR spectroscopy and magnetization measurements, respectively.
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