Unprecedented anion-pi interactions are revealed for the electron-poor triazine rings in [L2(CuCl)3][CuCl4]Cl (L = hexakis(pyridin-2-yl)-[1,3,5]-triazine-2,4,6-triamin), where both the chloride ion and a Cl atom of [CuCl4]2- are located approximately 3.15 A above the ring centroids, in excellent agreement with theoretical predictions for a Cl-...triazine complex. This confirms the importance of attractive anion-pi interactions for the supramolecular assembly of complexes with pi-electron-deficient heteroaromatics.

Use of a macrocyclic tetracarbene ligand, which is topologically reminiscent of tetrapyrrole macrocycles though electronically distinct, has allowed for the isolation, X-ray crystallographic characterization and comprehensive spectroscopic investigation of a complete set of {FeNO}(x) complexes (x = 6, 7, 8). Electrochemical reduction, or chemical reduction with CoCp2, of the {FeNO}(7) complex 1 leads to the organometallic {FeNO}(8) species 2. Its crystallographic structure determination is the first for a nonheme iron nitroxyl {FeNO}(8) and has allowed to identify structural trends among the series of {FeNO}(x) complexes. Combined experimental data including (57)Fe Mössbauer, IR, UV-vis-NIR, NMR and Kβ X-ray emission spectroscopies in concert with DFT calculations suggest a largely metal centered reduction of 1 to form the low spin (S = 0) {FeNO}(8) species 2. The very strong σ-donor character of the tetracarbene ligand imparts unusual properties and spectroscopic signatures such as low (57)Fe Mössbauer isomer shifts and linear Fe-N-O units with high IR stretching frequencies for the NO ligand. The observed metal-centered reduction leads to distinct reactivity patterns of the {FeNO}(8) species. In contrast to literature reported {FeNO}(8) complexes, 2 does not undergo NO protonation under strictly anaerobic conditions. Only in the presence of both dioxygen and protons is rapid and clean oxidation to the {FeNO}(7) complex 1 observed. While 1 is stable toward dioxygen, its reaction with dioxygen under NO atmosphere forms the {FeNO}(6)(ONO) complex 3 that features an unusual O-nitrito ligand trans to the NO. 3 is a rare example of a nonheme octahedral {FeNO}(6) complex. Its electrochemical or chemical reduction triggers dissociation of the O-nitrito ligand and sequential formation of the {FeNO}(7) and {FeNO}(8) compounds 1 and 2. A consistent electronic structure picture has been derived for these unique organometallic variants of the key bioinorganic {FeNO}(x) functional units.

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The ability of many copper metalloenzymes to activate O2 and transfer it to organic substrates has motivated extensive attention in the literature. Investigations focusing on synthetic analogues have provided a detailed understanding of the structures of potential intermediates, thereby helping to guide mechanistic studies. We report herein a crystallographically characterized synthetic Cu(II)2(μ-η(1):η(1)-O2) complex exhibiting cis-peroxo bonding geometry, known in iron chemistry but previously unobserved for copper. Detailed investigation by UV-vis, resonance Raman, and infrared spectroscopies provides evidence for a significantly diminished copper-oxygen interaction (ε ≈ 3000 M(-1) cm(-1), ν(Cu-O) = 437 cm(-1), ν(O-O) = 799 cm(-1)) relative to those in known 'coupled' Cu2O2 species, consistent with magnetic measurements which show that the peroxide mediates only weak antiferromagnetic coupling (-2J = 144 cm(-1)). These characteristics are comparable with those of a computationally predicted transition state for O2 binding to type 3 copper centers, providing experimental evidence for the proposed mechanism of O2 activation and supporting the biological relevance of the Cu(II)2(μ-η(1):η(1)-O2) cis-species. The peroxide bonding arrangement also allows binding of sodium cations, observed both in the solid state and in solution. Binding induces changes on an electronic level, as monitored by UV-vis spectroscopy (K(a) = 1700 M(-1)), reminiscent of redox-inactive metal binding by iron-oxygen species. The results presented highlight the analogous chemistry these reactive oxygen species undergo, with respect to both their mechanism of formation, and the molecular interactions in which they participate.

The new pyrazolate-bridged proligand 4-methyl-3,5-bis{6-(2,2'-bipyridyl)}pyrazole ((Me)LH) has been synthesized. Similar to its congener that lacks the backbone methyl substituent ((H)LH) it forms a robust Fe(II)4 grid complex, [(Me)L4Fe(II)4](BF4)4. The molecular structure of [(Me)L4Fe(II)4](BF4)4·2MeCN has been elucidated by X-ray diffraction, revealing two high-spin (HS) and two low-spin (LS) ferrous ions at opposite corners of the rhombic metal ion arrangement. SQUID and (57)Fe Mössbauer data for solid material showed that this [HS-LS-HS-LS] configuration persists over a wide temperature range, between 7 and 250 K, while spin-crossover sets in only above 250 K. According to Mössbauer spectroscopy a [1HS-3LS] configuration is present in solution at 80 K. Thus, the methyl substituent in [(Me)L](-) leads to a stronger ligand field compared to parent [(H)L](-) and hence to a higher LS fraction both in the solid state and in solution. Cyclic voltammetry of [(Me)L4Fe(II)4](BF4)4 reveals four sequential oxidations coming in two pairs with pronounced stability of the di-mixed-valence species [(Me)L4Fe(II)2Fe(III)2](6+) (K(C) = 3.35 × 10(8)). The particular [HS-LS-HS-LS] configuration as well as the di-mixed-valence configuration, both with identical spin or redox states at diagonally opposed vertices of the grid, make this system attractive as a molecular component for quantum cellular automata.

The reduction of 1,2‐bis[(2,6‐diisopropylphenyl)imino]acenaphthene (2,6‐iPr2C6H3‐BIAN) with metallic magnesium or calcium in THF affords the monomeric complexes (2,6‐iPr2C6H3‐BIAN)Mg(THF)3 (1) and (2,6‐iPr2C6H3‐BIAN)Ca(THF)4·(THF)1/2 (2). The crystallisation of 1 and 2 from benzene causes the removal of one of the coordinated THF molecules, yielding (2,6‐iPr2C6H3‐BIAN)Mg(THF)2·(C6H6)1/2 (3a) and (2,6‐iPr2C6H3‐BIAN)Ca(THF)3 (4). Repeated recrystallisation of 1 from benzene gives (2,6‐iPr2C6H3‐BIAN)Mg(THF)2·(C6H6)2 (3b). Although the crystals of 3a and 3b differ in colour and in their crystallographic parameters, their molecular dimensions are very similar. Recrystallisation of 1 from pyridine produces (2,6‐iPr2C6H3‐BIAN)Mg(py)3·(py)2 (5). Complexes 1−5 have been characterised by elemental analysis, UV, IR and 1H NMR spectroscopy, as well as by single‐crystal X‐ray diffraction. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)

From the study of highly preorganized model systems, experimental support has been obtained for a possible functional role of the Zn-(H)O...HO(H)-Zn motif in oligozinc hydrolases. The mechanistic relevance of such an array, which may be described as a hydrated form of a pseudo-terminal Zn-bound hydroxide, has recently been supported by DFT calculations on various metallohydrolase active sites. In the present targeted approach, the Zn...Zn distance in two related dizinc complexes has been controlled through the use of multifunctional pyrazolate-based ligand scaffolds, giving either a tightly bridged Zn-O(H)-Zn or a more loosely bridged Zn-(H)O...HO(H)-Zn species in the solid state. Zn-bound water has been found to exhibit comparable acidity irrespective of whether the resulting hydroxide is supported by strong hydrogen-bonding in the O(2)H(3) moiety or is in a bridging position between two zinc ions, indicating that water does not necessarily have to adopt a bridging position in order for its pK(a) to be sufficiently lowered so as to provide a Zn-bound hydroxide at physiological pH. Comparative reactivity studies on the cleavage of bis(4-nitrophenyl)phosphate (BNPP) mediated by the two dizinc complexes have revealed that the system with the larger Zn...Zn separation is hydrolytically more potent, both in the hydrolysis and the transesterification of BNPP. The extent of active site inhibition by the reaction products has also been found to be governed by the Zn...Zn distance, since phosphate diester coordination in a bridging mode within the clamp of two zinc ions is only favored for Zn...Zn distances well above 4 A. Different binding affinities are rationalized in terms of the structural characteristics of the product-inhibited complexes for the two different ligand scaffolds, with dimethyl phosphate found as a bridging ligand within the bimetallic pocket.