The reliability of immediately loaded dental implants in the mandible has prompted many to investigate their application in the maxilla. Although the body of literature is growing, the long-term survivability of immediate loading in the maxilla is still pending. This review of literature investigates the status of immediate loading of dental implants in the maxilla to determine its predictability as a treatment option for partial and complete maxillary edentulism. Current terminology in the field is summarized first. Subsequently, the rationale and advantages of immediate loading in the maxilla are reviewed, and the relationships between immediate loading and osseointegration, primary stability, implant design, micromotion, immediate implant placement, and bone character are explored. The importance of a prosthodontically driven implant treatment plan emphasizing the role of splinting a high-precision and passively fitting implant restoration with reduced micromotion under function is summarized. The reliability and predictability of immediately loaded implants as a treatment option are proposed, and recommended guidelines for the successful delivery of immediately loaded implants in the maxilla are presented.

This study investigated whether changes in GABA-mediated neurotransmission within the nucleus of the solitary tract (NTS) contribute to the changes in breathing (resting ventilation and the acute HVR) that occur following exposure to chronic hypoxia (CH). Rats were exposed to 9 days of hypobaric hypoxia (0.5 atm) and then subjected to acute hypoxic breathing trials before and after bilateral microinjections of GABA, bicuculline (a GABAA-receptor antagonist), or bicuculline plus CGP-35348 (a GABAB receptor antagonist) into the caudal regions of the NTS. Breathing was measured using whole body plethysmography. CH caused an increase in resting ventilation when the animals were breathing 30% O2 but did not alter ventilation during acute hypoxia (10% O2). GABA alone had no effect on breathing in either the control or chronically hypoxic rats. Bicuculline and bicuculline/CGP had no effect on breathing in control rats. Following CH, bicuculline and bicuculline/CGP reduced minute ventilation (VI) during acute exposure to 30% O2 but had no effect during acute exposure to 10% O2. The bicuculline-induced reduction in VI resulted from a decrease in breathing frequency (fR) and tidal volume (VT). The bicuculline/CGP-induced reduction in VI was due to a decrease in fR with no change in VT. The results suggest that changes in GABA receptor-mediated neurotransmission, within the NTS, are involved in the increase in resting ventilation that occurs following CH.

Our findings were contrary to previous findings of the effect of laser phototherapy on regulating the rate of OTM. Further investigations are warranted to analyse whether the duration or method of LED delivery would have an effect on the rate of OTM. Toronto. This trial was registered at clinicaltrials.gov (NCT01490385).

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