An electronic medical record (EMR)-based screening system has been developed as a trigger system for a rapid response team (RRT) that traditionally used direct calling. We compared event characteristics, intensive care unit (ICU) admission, and 28-day mortality following RRT activation of the two trigger systems. A total of 10,026 events were classified into four groups according to the activation time (i.e., daytime or on-call time) and the triggering type (i.e., calling or screening). Among surgical patients, the ICU admission was lowest for the on-call screening group (26.2%). Compared to the on-call screening group, the on-call calling group and daytime calling group showed higher ICU admission with an odds ratio (OR) of 2.07 (95% CI 1.50–2.84, p < 0.001) and OR of 2.68 (95% CI 1.91–3.77, p < 0.001), respectively. The 28-day mortality was lowest for the on-call screening group (8.7%). Compared to the on-call screening group, on-call calling (OR 1.88, 95% CI 1.20–2.95, p = 0.006) and daytime calling (OR 1.89, 95% CI 1.17–3.05, p < 0.001) showed higher 28-day mortality. The EMR-based screening system might be useful in detecting at-risk surgical patients, particularly during on-call time. The clinical usefulness of an EMR-based screening system can vary depending on patients’ characteristics.
BackgroundDiet has a crucial role in the gut microbiota, and dysbiosis in the gut and lungs has been suggested to be associated with chronic obstructive pulmonary disease. We compared the diet, microbiome and metabolome between asymptomatic smokers and those with emphysema.MethodsWe enrolled 10 asymptomatic smokers with preserved lung function and 16 smokers with emphysema with severe airflow limitation. Dietary intake information was gathered by a self-reported questionnaire. Sputum and faecal samples were collected for microbial and metabolomics analysis. A murine model of emphysema was used to determine the effect of metabolite supplementation.ResultsDespite having a similar smoking history with emphysema patients, asymptomatic smokers had higher values of body mass index, fibre intake and faecal acetate level. Linear discriminant analysis identified 17 microbial taxonomic members that were relatively enriched in the faeces of asymptomatic smokers. Analysis of similarity results showed dissimilarity between the two groups (r=0.287, p=0.003). Higher acetate level was positively associated with forced expiratory volume in one second in the emphysema group (r=0.628, p=0.012). Asymptomatic smokers had a greater number of species associated with acetate and propionate (r>0.6) than did those with emphysema (30 vs 19). In an emphysema mouse model, supplementation of acetate and propionate reduced alveolar destruction and the production of proinflammatory cytokines, and propionate decreased the CD3+CD4+IL-17+T-cell population in the lung and spleen.ConclusionSmokers with emphysema showed differences in diet, microbiome and short-chain fatty acids compared with asymptomatic smokers. Acetate and propionate showed therapeutic effects in a smoking-induced murine model of emphysema.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.