Conclusion:This discriminatory biomarker panel shows potential for BE diagnosis using an inexpensive, minimally invasive sampling technique and thus merits further study in case-control sponge studies. Due to our systematic and rigid method of selecting these markers, these genes are expected to be extremely important for the diagnosis of BE.
Introduction- Hiatal hernia repair is associated with substantial recurrence of both hiatal hernia and symptoms of gastroesophageal reflux (GER). While small randomized controlled trials demonstrate limited differences in outcomes with use of mesh or fundoplication type, uncertainty remains.
Methods- A multicenter, retrospective review of patients undergoing surgical treatment of hiatal hernias between 2015-2020 was performed. Patients with mesh and with suture only repair were compared, and partial versus complete fundoplication was compared. Primary outcomes were hernia recurrence and occurrence of post-operative GER symptoms and dysphagia. Multivariable regression was performed to assess the effect of each intervention on clinical outcomes.
Results- A total of 453 patients from four sites were followed for a median (IQR) of 17 (13) months. On multivariate analysis, mesh had no impact on hernia recurrence (odds ratio 0.993, 95% CI 0.53-1.87, p=0.982), and fundoplication type did not impact recurrence of post-operative GER symptoms (complete: odds ratio 0.607, 95% CI 0.33-1.12, p=0.112) or dysphagia (complete: odds ratio 1.17, 95% CI 0.56-2.43, p=0.677).
Conclusion- During hiatal hernia repair, mesh and fundoplication type do not appear to have substantial impact on GER symptoms, dysphagia, or hernia recurrence. This multicenter study provides real-world evidence to support the findings of small RCTs.
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