Rotavirus infection is a frequent cause of gastroenteritis in children and accounts for significant morbidity and mortality, especially in the developing world. Less well recognized is the association of rotavirus-induced central nervous system dysfunction, which has been associated with seizure, encephalopathy, and death. Symptoms may vary widely, however, and children can experience short afebrile convulsions as the only manifestation of rotavirus encephalopathy. We report 4 further cases of rotavirus-induced seizures with mild neurologic manifestations. The condition is reviewed and practical management strategies are suggested.

Typically, the Winter Simulation Conference has generally focused on Discrete Event Simulation and Capacity Modeling. This paper will discuss integration of several of the engineering simulation systems involved in the design and manufacturing of capital intensive products. The purpose of this paper is to foster discussion on the benefits of an integrated data environment for design through production.