Introduction. Cardiovascular mortality in patients diagnosed with seronegative spondyloarthritis (SSN) is on the rise. Impairment of the cardiovascular system in ankylosing spondylitis (SpA) is 20-40%, in psoriatic arthritis (APs) 18-22% and in reactive arthritis (ARe) 1-3%.Material and methods. The study included 77 patients diagnosed with SSN. Laboratory (erythrocyte sedimentation rate – ESR, C-reactive protein – CRP, fibrinogen) and instrumental (echocardiography – EcoCG, electrocardiogram – ECG) data were analyzed.Results. In 35 patients diagnosed with SpA, the left branch hemiblock of the Hiss bundle was determined – 71% and bradycardia – 57%. Aortic valve (VAo) changes were diagnosed in 54% and left ventricular hypertrophy (LVH) in 57%. Elevated CRP values were found in 34.5% of cases, ESR – 22.8% and fibrinogen – 17.2%. In 24 patients with APs, 33.5% showed VAo induration and fibrosis. Another change diagnosed in these patients was LVH (37.5%). Cardiac conductivity disorders in 25% were due to the left branch hemiblock of the Hiss bundle, and among the increased inflammatory markers were: fibrinogen (16.6%) and CRP (12.5%). In 18 patients with ARe as a rhythm disorder, tachycardia is predominant – 94% and VAo damage in 27.7%. Inflammatory markers with values above the upper limit were fibrinogen (66%) and CRP (33%).Conclusions. Our study showed that SSN is closely related to the inflammatory syn-drome, on which the activity of the disease and the degree of damage to the cardiovascular system depend. Most often the heart is affected with its components.
Introduction. With syntropy of CVD and AH, the pathology of the digestive system can exacerbate the course of AH and develop special conditions for increasing the risk of cardiovascular complications. Pharmacotherapy of HD may affect the course and progression of gastroesophageal reflux disease. Material and methods. The study was conducted using the PubMed, Z-library, NCIB, Medscape, Mendeley databases using the keywords: “syntropy”, “comorbidity”, “arterial hypertension”, “acid-dependent diseases”, “gastric ulcer”, “gastroesophageal reflux disease”. Results. AH and CVD are quite often observed together, having, moreover, a conditioned commonality of the mechanisms of formation. The proximity of the location with the heart, the commonality of innervation, in the pathology of the esophagus, can create viscero-visceral reflexes and provoke arrhythmias, imitate coronary heart disease. Pathology of the upper gastrointestinal tract can lead to functional disorders of the cardiovascular system, manifested through the autonomic nervous system. The combined course of AH and CVD, observed, according to various sources, from 11.6% to 50%, is not just random, but may have pathogenetic and etiological patterns. Comorbidity of CVD and AH can enhance the development of the main pathological process and lead to disruption of adaptive mechanisms. Conclusions. The syntropy of AH and CVD requires thorough scientific studies to discover and elucidate the pathogenetic features of the course and methods of better drug therapy.
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