We present a quantitative synthesis of trophic cascades in terrestrial systems using data from 41 studies, reporting 60 independent tests. The studies covered a wide range of taxa in various terrestrial systems with varying degrees of species diversity. We quantified the average magnitude of direct effects of carnivores on herbivore prey and indirect effects of carnivores on plants. We examined how the effect magnitudes varied with type of carnivores in the study system, food web diversity, and experimental protocol. A metaanalysis of the data revealed that trophic cascades were common among the studies. Exceptions to this general trend did arise. In some cases, trophic cascades were expected not to occur, and they did not. In other cases, the direct effects of carnivores on herbivores were stronger than the indirect effects of carnivores on plants, indicating that top-down effects attenuated. Top-down effects usually attenuated whenever plants contained antiherbivore defenses or when herbivore species diversity was high. Conclusions about the strength of top-down effects of carnivores varied with the type of carnivore and with the plant-response variable measured. Vertebrate carnivores generally had stronger effects than invertebrate carnivores. Carnivores, in general, had stronger effects when the response was measured as plant damage rather than as plant biomass or plant reproductive output. We caution, therefore, that conclusions about the strength of top-down effects could be an artifact of the plant-response variable measured. We also found that mesocosm experiments generally had weaker effect magnitudes than open-plot field experiments or observational experiments. Trophic cascades in terrestrial systems, although not a universal phenomenon, are a consistent response throughout the published studies reviewed here. Our analysis thus suggests that they occur more frequently in terrestrial systems than currently believed. Moreover, the mechanisms and strengths of top-down effects of carnivores are equivalent to those found in other types of systems (e.g., aquatic environments).

Indirect effects emerge when a change in the abundance of one species indirectly affects another by changing the abundances of intermediate species-called density-mediated indirect effects-or they arise when one species modifies how two other species interact-called trait-mediated indirect effects. I report on field experiments that evaluated how grass and herb biomass in old-field interaction webs was influenced indirectly by a spider carnivore through its interactions with a generalist and a grass-specialist grasshopper species. I manipulated interaction pathways between the spider and the plants using different combinations of the grasshopper species. I changed the modality of predator-prey interactions to isolate density-mediated from trait-mediated effects using natural spiders (predation spiders) or spiders that were prevented from subduing prey by mouthpart manipulation (risk spiders). I found that indirect effects were stronger in speciose, reticulate food webs than in linear food chains owing to a trait-mediated effect, a diet shift by herbivores in response to predation risk. Spiders alone did not have significant effects on grasshopper densities in the field experiments, removing any possibility of density-mediated indirect effects. The study illustrates that ecologists should not underestimate the importance of behavioral ecology in determining community-level interactions.

Background: Several studies have shown that treatment with omeprazole leads to aggravation of Helicobacter pylori gastritis in the corpus. Whether this also applies to lansoprazole, and whether, in comparison with omeprazole, there are differences in therapy‐induced gastritis parameter changes remains unclear. Methods: In 111 patients infected with H. pylori and with gastro‐oesophageal reflux disease we investigated the gastritis parameters in antral and corpus mucosa before and after 2, 6 and 12 months of treatment with 15 or 30 mg lansoprazole or 20 mg omeprazole/day. Results: In all groups the different treatments had a similar effect: in both regions of the stomach, suppression or partial elimination of H. pylori was seen. However, improvement in the inflammation was observed only in the antrum, while in the corpus most gastritis parameters worsened significantly. There was no increase in intestinal metaplasia or atrophy. Conclusion: In common with omeprazole, lansoprazole aggravates the gastritis parameters in the corpus but improves them in the antrum. Treatment with proton pump inhibitors does not result in any increase in the incidence of atrophy/intestinal metaplasia. However, as gastritis predominating in the corpus seems to be associated with an elevated carcinogenic risk, consideration should be given to prophylactic H. pylori eradication therapy before initiating proton pump inhibitor treatment.

To begin identifying what behavioral details might be needed to characterize community dynamics and stability, we examined the effect of prey behavioral responses to predation risk on community dynamics and stability. We considered the case of prey altering their foraging effort to trade off energy gain and predation risk. We used state-dependent dynamic optimization to calculate the optimal trade-off for four models of prey behaviorally responding to predation risk. We consider a fixed behavior model in which prey use constant levels of foraging effort and three flexible behavior models in which prey change their foraging effort according to their physiological state and their perceived level of predation risk. Flexible behavior was destabilizing at the community level as evidenced by higher predator-prey oscillations and lower community persistence times. The mechanisms by which prey estimated predation risk also affected community stability. We found that community dynamics resulting from prey with flexible behavior and fixed perception of risk approximated community dynamics resulting from prey with flexible behavior and perfect information about predation risk, however neither approximated the community dynamics resulting from prey with flexible behavior and flexible perception of risk. Thus, whether it might be possible to abstract complex behavior with simpler rules when modeling community dynamics depends on the prey's behavioral mechanisms, which are empirically poorly known.

Context. Galaxy imaging surveys observe a vast number of objects, which are ultimately affected by the instrument’s point spread function (PSF). It is weak lensing missions in particular that are aimed at measuring the shape of galaxies and PSF effects represent an significant source of systematic errors that must be handled appropriately. This requires a high level of accuracy at the modelling stage as well as in the estimation of the PSF at galaxy positions. Aims. The goal of this work is to estimate a PSF at galaxy positions, which is also referred to as a non-parametric PSF estimation and which starts from a set of noisy star image observations distributed over the focal plane. To accomplish this, we need our model to precisely capture the PSF field variations over the field of view and then to recover the PSF at the chosen positions. Methods. In this paper, we propose a new method, coined Multi-CCD (MCCD) PSF modelling, which simultaneously creates a PSF field model over the entirety of the instrument’s focal plane. It allows us to capture global as well as local PSF features through the use of two complementary models that enforce different spatial constraints. Most existing non-parametric models build one model per charge-coupled device, which can lead to difficulties in capturing global ellipticity patterns. Results. We first tested our method on a realistic simulated dataset, comparing it with two state-of-the-art PSF modelling methods (PSFEx and RCA) and finding that our method outperforms both of them. Then we contrasted our approach with PSFEx based on real data from the Canada-France Imaging Survey, which uses the Canada-France-Hawaii Telescope. We show that our PSF model is less noisy and achieves a ∼22% gain on the pixel’s root mean square error with respect to PSFEx. Conclusions. We present and share the code for a new PSF modelling algorithm that models the PSF field on all the focal plane that is mature enough to handle real data.

We report on a 27-year-old male Caucasian with severe haemophilia A who presented with acute onset of neck pain with cervical nerve root irritation, due to a spinal epidural haematoma. His past medical history revealed carrying of a moderate weight as a possible traumatic mechanism. Under immediate factor VIII replacement therapy complete remission of the symptoms was achieved within several days. The diagnosis of spinal epidural haematoma and complete resorption was revealed by initial and follow-up magnetic resonance imaging studies of the cervical spine. Having reviewed the literature on spinal epidural haematoma, we present an overview of the treatment and outcome as regards haemophilia.

Intrahepatic cholangiocarcinomas (ICC) are neoplasms that originate from cholangiocytes and can occur at any level of the biliary tree. Surgical resection is the current therapy of choice for this highly aggressive cancer. However, the 5-year survival still is poor, with high recurrence rates. Due to the intrahepatic growth a significant proportion of patients present with advanced disease and are not candidates for curative surgery or transplantation. The existing palliative options are of limited benefit and there is a great necessity for novel therapeutic options. In this article we review the role of the phosphoinositide 3-kinase(PI3K)/ AKT and extracellular regulated kinase (ERK) signaling pathways in ICC and present new data on the prognostic value of these protein kinases. Finally, we discuss future upcoming therapeutic options based on targeting these signaling pathways.

The human gastric mucosa adapts to prolonged aspirin intake, and this is accompanied by an increase in mucosal blood flow and reduced prostaglandin synthesis. Increase of mucosal eNOS expression might compensate for reduced prostaglandin synthesis and be responsible for gastric adaptation to chronic aspirin intake in humans.