Objective: To study patients with symptoms suggestive of obstructive sleep apnoea using overnight oxymetry, and describe their symptoms, risk factors and co-morbidities. Methodology: Overnight oxymetry was carried out on consecutive patients presenting with snoring and daytime sleepiness. Daytime sleepiness was assessed with Epworth sleepiness score (ESS). Their body mass index (BMI), presence of hypertension, neck circumference, oropharyngeal Mallampathi index, thyroid status, co-morbidities, alcohol, smoking, and medication use were noted. The number of oxygen desaturations below 4% of the baseline, per hour of sleep (oxygen desaturation index: ODI) was calculated and a plot of oxygen saturation versus time was analyzed for graph morphology. Association of ODI with other clinical parameters was statistically analyzed. Results: Forty five patients (15 females) with a mean age of 44 (±13) years underwent overnight oxymetry. Their mean BMI was 27.62 (±8.82) kg/m2, 11(24%) were obese (BMI ≥30kg/m2) and 21 (46%) were hypertensive. They complained of snoring (91%), nocturnal waking up (82%), nocturnal choking (35 %), witnessed apnoeic episodes (31%), waking up tired (16%), nocturia (31%) and waking up with headache (20%). Mean ODI was 9.32 (±9.66)/hr. Twenty six (57%) patients had an abnormal ODI above 5/hr with saw tooth appearance in oxymetry tracings and 33% of them had an ODI ≥10/hr. Hypertension, nocturia and ESS showed a significant association with ODI (P 0.05). ODI significantly correlated with ESS (P=0.02) and BMI (P=0.006). Conclusion: Sleep apnoea is prevalent than expected, though largely unrecognized. Obesity, higher Epworth score, nocturia and hypertension indicated risk factors for OSAS. Use of widely
Objective: To critically analyze the outcome of sputum negative pulmonary TB patients who were managed in the Respiratory unit, Kandy Sri Lanka. Setting: Respiratory Unit, Teaching hospital, Kandy. Method: The subjects were between age 12 years or older and visited chest clinic Kandy, between January -December 2008 with a suspicion of pulmonary TB. 84 patients were reviewed with admission note, microbiology results and chest radiography. The characteristics of patients such as age, sex, clinical features, laboratory and radiographic findings were analyzed. Results: The diagnosis of definite or probable smear negative pulmonary TB was made on treatment outcome at one month with ATT medication. At this endpoint, 67 (79.76%) had clinical and radiological improvement, 7(8.33%) had clinical improvement and 3 (3.57%) had radiological improvement. Mantoux test was positive in 46(78%) of definite cases and 6(85.7%) in probable cases. Mycobacterial culture was positive in 5 patients. 7 (8.3%) cases were diagnosed as ‘non-TB’ based on absence of clinical / radiological improvement or discovery of another cause at or before this study end point. In non TB group 3 had carcinoma, 2 had pneumoconiosis, 1 had bronchiectasis while in 1, cause was indeterminate. Mantoux became positive in 6 (83.3%) in non Tuberculosis group. There was no association between positive Mantoux and presence of active pulmonary TB. Conclusion: Our findings suggest that empirical anti TB treatment is an acceptable practice if clinical suspicion of tuberculosis is high and patients show supportive radiological evidence of active TB. Keywords: Smear negative pulmonary tuberculosis; empirical anti tubercular treatment DOI: 10.3126/saarctb.v7i2.4400SAARC J. TUBER. LUNG DIS. HIV/AIDS 2010 VII(2) 15-18
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.