Objective: To determine plasma omentin-1 levels in pregnant females suffering from gestational diabetes mellitus. Study Design: Case Control study. Setting: Outpatient Department of Obstetrics and Gynecology, Tertiary Care Hospital of Karachi, Pakistan. Period: June 2021 to December 2021. Material & Methods: Ninety-nine gestational diabetic and ninety-six healthy pregnant women were included in this study. A diagnostic criterion for gestational diabetes was oral glucose tolerance test between 24th to 28th weeks of pregnancy. ELISA was performed at KIBGE lab for estimation of plasma omentin-1 levels. Data was analyzed by SPSS software version 22. Results: Mean age of the patients was 30.8±6.4 years. GDM patients had increased BMI (36.0± 6.6vs 32.3 ±4.7; p=0.001), FBG (110 ±14 vs 77± 9; p=0.001), however, plasma omentin-1levels (4.90±9.01vs 9.56±12.11; p=0.001) were found reduced in GDM as compared to nGDM females. Statistically significant negative correlation was found between plasma omentin-1 and body mass index (BMI) (p=0.02). Simple and multi variable regression analysis revealed the statistically significant association of plasma omentin-1 with GDM. Conclusion: Our study has concluded that reduced plasma omentin-1 levels may play a significant role in the development of GDM during pregnancy, so it might be a new possible biomarker for early GDM diagnosis.
Objective: To asses if Topical probiotics and steroids can accelerate the process of angiogenesis in wound repair. Study Design: Longitudinal Experimental study. Setting: Al-Tibri Medical College. Period: Jan 2020 to Dec 2020. Material & Methods: Total 72 male albino rats were acquired from the animal house of the institution, and 18 as a requirement of per day of sampling included 6 animals/gp. An equal size incision of (2x2cm2) was made in all the animals. Group A was given Topical Normal Saline (Control Group), Group B was given the Probiotic (Lactobacillus Acidophilus), and Group C was given Topical Steroid (Dexamethasone). Samples from the wound created surgically was obtained on the 3rd, 7th, 14th, and 21st Day and slides were created to observe the number of blood vessels formed and angiogenesis under a light microscope. Data was analyzed using SPSS version 21.0. To compare the mean between the groups, the ANOVA was applied along with post hoc Tukey's test. The level of significance was considered P≤0.05. Results: The mean number of blood vessels formed in Group A (Control Group) was 2.75, 4, 5.25, and 5.50, in Group B (Probiotics Group) was 10, 13.50, 2.25, and 1, and in Group C (Steroid Group) was 3.75, 5.50, 3, and 2.25 on the 3rd, 7th, 14th, and 21st Day respectively. Significant difference was seen in the mean number of blood vessels formed when the Probiotic group was compared to Group A and C. Conclusion: Topical Probiotic accelerates the process of angiogenesis in wound repair due to their anti-inflammatory response.
The metabolic syndrome is a group of factors including central obesity, dyslipidemia, hypertension, and impaired glucose tolerance, with obesity being the most significant aspect. The influence of gene variants involved in hormone synthesis or action could explain the conflicting results when considering the relationship between visfatin plasmatic levels and obesity. However, there is a lack of research on these polymorphisms. This study found that the SNPs for visfatin rs2302559 and rs1215113036 were statistically significantly associated with the metabolic factors at p value 0.001 and odd ratio suggested that there is a great chance of developing the disorder if these variations are present up to at 129.40. Frequency of the mutant alles were to be found in higher in frequency.
Objectives: To determine the correlation of perceived stress with blood pressure and pulmonary function tests in normal, healthy first-year medical students. Study Design: Cross Sectional study. Setting: Department of Physiology, Al-Tibri Medical College, Isra University Karachi Campus. Period: August 2021 to February 2022. Material & Methods: From all the students enrolled in the first year MBBS during academic year 2021-22, data from 72 students were evaluated who met the inclusion criteria. The sphygmomanometer was used to measure the blood pressure parameters, and the Biopac ® data acquisition system was used to measure the pulmonary function test variables. A ten-item classic stress assessment questionnaire was used to evaluate the perceived stress scale, and the observed values were then correlated with the variables of blood pressure and pulmonary function tests. Results: The majority of the study cohort (69.44%) is in a moderate level of stress with female predominance (p= 0.001), while diastolic blood pressure (p=0.008), mean arterial blood pressure (p=0.006), vital capacity (p=0.000), forced vital capacity (p=0.006), forced expiratory volume in the first second (p=0.003) all negatively correlated with perceived stress scale in the participants. Conclusion: The findings of the present study point toward possible delirious effects of stress on cardio-pulmonary health. The timely detection and address budding stress issues in the early years of medical schools by establishing counseling and preventive mental health services centers will prevent future morbidity and produce healthy doctors.
Objective: To evaluate the restoration of sperm motility with the antioxidant oils (Virgin coconut oil and Corn oil) therapy in Phenytoin induced testicular toxicity of rats. Study Design: Experimental Study. Setting: Al-Tibri Medical College and Hospital. Period: November 2019 to March 2020. Material & Methods: Forty-eight male albino rats weighing between 150-250gms were taken from the animal house of Al-Tibri medical college and placed in 4 groups, each with 12 rats. Group A was the control group receiving saline, Group B received Phenytoin only, Group C received Phenytoin and Virgin coconut oil, and Group D received Phenytoin and Corn oil. The rats were euthanized on the 4th, 5th, and 6th week of the study. Their epididymis was cut, and the epididymal fluid was placed under the microscope to determine sperm motility. Data was analyzed using SPSS Version 20.0 with one-way ANOVA followed with Post-Hoc Tukey’s test to compare statistical significance. Results: The significant difference was seen in mean % sperm motility when comparing Group B vs. A (≤0.001) and Group B vs. C (≤0.001) during the 4th, 5th, and 6th. Conclusion: Virgin Coconut Oil and Corn Oil both restored sperm motility. A higher percentage was observed in Virgin Coconut Oil received rats, which proved effective in resurging sperm motility.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.