Xerostomia merupakan sensasi subjektif mulut kering yang dapat menyebabkan berbagai masalah di rongga mulut danmempengaruhi kualitas hidup seseorang. Xerostomia sering terjadi sebagai efek samping penggunaan obat dan salah satuobat yang dapat menyebabkan xerostomia adalah obat bronkodilator yang digunakan pasien penyakit paru obstruktifkronik (PPOK). Tujuan penelitian untuk mengetahui hubungan penggunaan obat bronkodilator terhadap terjadinyaxerostomia pada pasien penyakit paru obstruktif kronik (PPOK) berdasarkan jenis dan lama pemberian obat. Jenispenelitian ini adalah survei analitik dengan pendekatan cross sectional melibatkan 97 subjek (75 orang laki-laki dan 22orang perempuan) yang merupakan pasien PPOK di RSU Dr. Pirngadi Medan. Penelitian ini dilakukan denganmewawancarai subjek menggunakan alat bantu kuesioner. Data diproses secara komputerisasi dan analisis menggunakanuji Chi square. Hasil penelitian menunjukkan pasien PPOK yang mengalami xerostomia sebanyak 63 orang (64,95%).Persentase xerostomia paling tinggi terdapat pada pengguna kombinasi obat (agonis beta 2 dan antikolinergik) danberdasarkan lama pemberian obat paling tinggi terdapat pada pengguna obat selama 1-5 tahun. Sebagai kesimpulan,ditemukan adanya hubungan yang signifikan antara jenis obat dan lama pemberian obat bronkodilator yang digunakanpasien PPOK terhadap terjadinya xerostomia. Penggunaan kombinasi obat dan dengan durasi yang semakin lama akansemakin meningkatkan resiko terjadinya xerostomia.
Oral potentially malignant disorders have been associated with a betel quid chewing habit. To date, betel quid chewing has a major social and cultural role in the society of Samosir Island, North Sumatra, Indonesia. The purpose of the present study was to evaluate the occurrence of oral potentially malignant disorders associated with the habit of betel quid chewing in the society of Samosir Island, North Sumatra, Indonesia. This case-control study was conducted on all betel quid chewers in the working area of the Ambarita Public Health Centre in Samosir Regency, North Sumatra, Indonesia. All subjects were examined clinically for the presence of any oral lesions and interviewed for their betel quid chewing habit. Chi-square and Fisher’s exact tests were used to analyze the relationship between variables. Among the 51 subjects recruited in the study, 28 subjects suffered from oral potentially malignant disorders who had oral potentially malignant disorders such as submucous fibrosis and/or leukoplakia (the case group) whereas 23 subjects showed no clinically detectable oral potentially malignant disorders (the control group). An increased risk of oral potentially malignant disorders was associated with the habit of chewing areca nut and tobacco (OR=1.600; p=0.542), the duration of betel quid chewing more than 25 years (OR=4.379; p=0.023), and the frequency of betel quid chewing more than 6 times/day (OR=4.800; p=0.021). In conclusion, oral potentially malignant disorders were associated with chewing betel quid habit in the society of Samosir Island, North Sumatra, Indonesia.
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