Background: High-risk pregnancy, as a traumatic event, could cause postpartum disorders; thus, these women need psychological therapy. Objectives: This study aimed to determine the efficacy of combination of cognitive-behavioral therapy and resiliency training based on Islamic spirituality instructions and cognitive flexibility on postpartum depression, fear of labor pain, and quality of life. Methods: This was a semi-experimental study with a pretest-posttest design and a control group. It was performed among 40 pregnant women who had visited Bandar Abbas health centers. The participants were placed in two groups of control and experimental. Data collection was carried out using quality of life: SF12, postpartum depression by Edinburg, and fear of labor pain (FPQ-111) in the three stages of before, after and two months after the intervention. Data were analyzed using descriptive statistics and analysis of variance test. Results: We found that the effect of combination of cognitive-behavioral therapy and resiliency training based on Islamic spirituality instructions and cognitive flexibility on postpartum depression (P < 0.01), fear of labor pain (P < 0.01), and the quality of life (P < 0.01) was significant, and the difference between the two groups was significant (P < 0.01). Conclusions: Trainings based on Islamic instructions were effective on reducing postpartum traumatic symptoms.