Multi Drugs Resistance (MDR) bacteria are mostly resistant to most of antibiotics, this leads to several severe infections and diseases. Thus the desire of new antibiotic sources are required which direct to the screening of new medicinal plants and use against MDR pathogenic bacteria. In our study, the antibacterial activity of three different plant extracts are utilized against pathogenic bacteria in-vitro to treat the infection and disease cause by pathogenic bacteria. The extracts were isolated from Mallotus philippensis, Silybum marianum and Stachys parviflora Benth in four different solvents extracts and were tested against eight pathogenic MDR bacterial strains (Brucella abortus, Escherichia coli, Enterobacter sakazakii, Proteus vulgaris, Klebsiella pneumoniae, Providencia stuartii, Pseudomonas aeruginosa (gram negative) and Staphylococcus aureus (gram positive) through well diffusion and disc diffusion. It was found that the extracts of selected plants showed maximum activity against all bacterial strains. The recorded zones of inhibition were 8.0-26.33mm for methanolic, 6.0-17.66mm for chloroform extracts and 8.01-2.33mm for ethyl acetate extracts. So, it is cleared from the results that the tested plant extracts have great potential as antibacterial compounds against bacteria. However, further research is required to isolate and identify the active ingredients are vital for further pharmacological evaluation. Also screening of these plants for Anticancer and Anti-diabetic activity will be significant.
The need of effective and economical antibiotics and antimicrobials has led to search for novel sources such as medicinal plants, fungi, archaea etc. In the present study, Daphne mucronata and Mallotus philippensis methanolic extracts were screened as antibacterial agents compared to some antibiotics against eight local isolates of human pathogenic bacteria. The susceptibility test was performed through well diffusion and disc diffusion method. Results reported that D. mucronata showed significant antibacterial activity against all the selected strains. The highest zones of inhibition of D. mucronata seed extract were recorded against, Providencia stuartii (20mm), Brucella abortus (19.3mm), Proteus vulgaris (19.3mm), Klebsiella pneumonia (19mm), followed by Pseudomonas aeruginosa (19mm), Enterobacter sakazaki (18.3mm), Escherichia coli (16.6mm) and Staphylococcus aureus (16.6mm). D. mucronata seed extract was reported as the most active against B. abortus (19.3mm), E. sakazaki (18.3mm), E. coli (16.6mm) and K. pneumoniae (19mm) when compared to Cefepime (8.1mm) and Ciprofloxacin (14.2mm). However, D. mucronata methanolic seed extract showed about similar antibacterial activity against P. vulgaris (19.3mm), P. stuartii (20mm), P. aeruginosa (19mm) and S. aureus (18.7mm), compared to the following antibiotics Cefepime (19.3mm) Ciprofloxacin (21mm), Moxifloxacin (21mm) and Ceftriaxone (20mm). On the other hand, M. philippensis showed insignificant antibacterial activity against the selected bacterial strains, but not significant compared to selected antibiotics. As conclusion, D. mucronata extract was considered as high potential antibacterial and recommend to be used as novel and economical source of effective antibacterial agent to combat against h u m a n p a t h o g e n i c b a c t e r i a .
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