The synthetic application of nickel catalysts in Heck-coupling reactions is quite prominent and noticeable of late in organic synthesis. It shows great interest over the other transition metal catalysts due to its unique characteristic that prepares them more significantly applicable in different fields of synthetic application. The usefulness of nickel-catalysts relies in the fact that they are abundant in nature, relatively less precious and environment friendly. Nickel plays pivotal role in different kind of Heck reactions known such as intramolecular-, intermolecular-, reductive-Heck type reaction producing mainly carbocycles and hetero cycles of biological significance. Carbocyclization or hetero-cyclization reaction occurred under optimized reaction conditions developed and come up with the formation of various structural building blocks of naturally occurring compounds. Via reductive Heck cyclization large membered ring of carbo-or hetero-cyclic system was formed which performed key role as building blocks in pharmaceutical synthesis and bioactive molecule formation. Intermolecular Heck type reactions were comparatively more explored. Silyl-Heck, carbonyl-Heck, and other miscellaneous type reactions were covered up through nickel-catalyzed intermolecular Heck reaction. Asymmetric versions of Heck-coupling reactions are also reported to proceed even with unactivated alkenes, offering molecules having quaternary stereogenic center in a regio-and enantioselective manner. This manuscript intends to cover these entire concepts.

The hydroarylation of alkynes, alkene, and, allene is a cost-effective and efficient way to incorporate unsaturated moieties into aromatic substrates. This review focuses on gold-catalyzed hydroarylation, which produces aromatic alkenes,...

Of late, developing non‐precious catalytic protocol with high performance is of primary significance and furnishes fascinating sets of results for synthetic chemists. This minireview describes the advances and scopes of nickel nanoparticles being employed as catalysts in Heck cross‐coupling reactions of aryl halides and olefins in 21st century. We have focused on the methods of preparation of nanocatalysts and emphasized on different techniques employed in the generation of nickel nanoparticles or bimetallic alloy nanoparticles.

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This article describes the recent advances in the field of nickel-catalyzed hydroarylation reaction of alkenes, alkynes, and arenes. All reactions proceeded either through internal hydride transfer or in presence of...