Three novel quaternary indole alkaloids with an unprecedented 1-azoniatricyclo[4.3.3.0(1,5)]undecane moiety, subincanadines A-C (1-3), as well as two new indole alkaloids with a 1-azabicyclo[5.2.2]undecane moiety, subincanadines D (4) and E (5), and a new indole alkaloid with a 1-azabicyclo[4.3.1]decane moiety, subincanadine F (6), have been isolated from the barks of Aspidosperma subincanum Mart, and the structures of 1-6 and the stereochemistry of 1-3 were elucidated by spectroscopic data and chemical means.
Two new cembrane diterpenoids with an eight-membered lactone ring, echinodolides A (1) and B (2), were isolated from the leaves of the Brazilian medicinal plant Echinodorus macrophyllus ("Chapéu-de-couro"), and the structures and relative stereochemistry were elucidated from their spectroscopic data.
AlkaloidsAlkaloids U 0600 Subincanadines A-C, Novel Quaternary Indole Alkaloids from Aspidosperma subincanum. -Title alkaloids (I) as well as subincanadines D-F (II) and (III) are tested for their cytotoxic activity, but only subincanadines E(IIb) and F(III) exhibit cytotoxicity in vitro. -(KOBAYASHI*, J.; SEKIGUCHI, M.; SHIMAMOTO, S.; SHIGEMORI, H.; ISHIYAMA, H.; OHSAKI*, A.; J. Org. Chem. 67 (2002) 18, 6449-6455; Grad. Sch. Pharm. Sci., Hokkaido Univ., Sapporo 060, Japan; Eng.) -Klein 06-189
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