Wound assessment is essential for evaluating wound healing. One cornerstone of wound care practice is the use of clinical guidelines that mandate regular documentation, including wound size and wound tissue composition, to determine the rate of wound healing. The traditional method requires wound care professionals to manually measure the wound area and tissue composition, which is time-consuming, costly, and difficult to reproduce. In this work, we propose an approach for automatic wound assessment that incorporates automatic color and measurement calibration and artificial intelligence algorithms. Our approach enables the comparison of images taken at different times, even if they were taken under different lighting conditions, distances, lenses, and camera sensors. We designed a calibration chart and developed automatic algorithms for color and measurement calibration. The wound area and wound composition on the images were annotated by three physicians with more than ten years of experience. Deep learning models were then developed to mimic what the physicians did on the images. We examined two network variants, U-Net with EfficientNet and U-Net with MobileNetV2, on wound images with a size of 1024 × 1024 pixels. Our best-performing algorithm achieved a mean intersection over union (IoU) of 0.6964, 0.3957, 0.6421, and 0.1552 for segmenting a wound area, epithelialization area, granulation tissue, and necrotic tissue, respectively. Our approach was able to accurately segment the wound area and granulation tissue but was inconsistent with respect to the epithelialization area and necrotic tissue. The calibration chart, which helps calibrate colors and scales, improved the performance of the algorithm. The approach could provide a thorough assessment of the wound, which could help clinicians tailor treatment to the patient’s condition.
Over time, large amounts of clinical data have accumulated in electronic health records (EHRs), making it difficult for healthcare professionals to navigate and make patient-centered decisions. This underscores the need for healthcare recommendation systems that help medical professionals make faster and more accurate decisions. This study addresses drug recommendation systems that generate an appropriate list of drugs that match patients’ diagnoses. Currently, recommendations are manually prepared by physicians, but this is difficult for patients with multiple comorbidities. We explored approaches to drug recommendations based on elderly patients with diabetes, hypertension, and cardiovascular disease who visited primary-care clinics and often had multiple conditions. We examined both collaborative filtering approaches and traditional machine-learning classifiers. The hybrid model between the two yielded a recall at 5 of 76.61%, a precision at 5 of 46.20%, a macro-averaged area under the curve of 74.52%, and an average physician agreement of 47.50%. Although collaborative filtering is widely used in recommendation systems, our results showed that it consistently underperformed traditional classification. Collaborative filtering was sensitive to class imbalances and favored the more popular classes. This study highlighted challenges that need to be addressed when developing recommendation systems in EHRs.
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