Background Elevated Serum uric acid (SUA) is strongly associated with cardiovascular risk factors such as dyslipidemia. It, however, is debated whether it itself is a risk factor of stroke. We therefore investigated the relation between serum UA levels and acute ischemic stroke.Material and Methods A case-control study on patients with acute ischemic stroke presenting at MM Institute of Medical Sciences & Research, Mullana, Haryana, North India was carried out from July, 2019 to September, 2020. The controls consisted of normal individuals attending the OPD similar to the cases in terms of age and gender. Serum levels of uric acid, lipid profile and other biochemical investigations of the cases were carried in the first 24 hours of admission.Results Out of the total 50 cases and 50 controls, 27(54.0%) were males and rest 23(46.0%) were females. Mean ages of the cases and the controls were 60.46 ±12.30 and 60.21±12.12 years respectively. The mean serum uric acid level of the cases was 6.49±2.36 mg/dL whereas mean serum uric acid level of the controls was 5.59±0.98 mg/dL, the difference being statistically significant(p=0.01). Similarly, 22(44.0%) out of the 50 cases were hyperuricemic whereas only 8(16.0%) out of the 50 controls were hyperuricemic, the difference in prevalence being statistically significant too(p=0.002). Dyslipidaemia was found in 40 (80.0%) cases as compared to 10(20.0%) controls(p<0.0001)Conclusion Elevated SUA level is significantly associated with the occurrence of acute ischemic stroke and may be considered a risk factor for acute ischemic stroke.
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