We describe here an easy and efficient method to obtain s-alkylated derivatives of thio-quinazolinone using different alkylating agents via a solvent-free microwave-assisted method. The alkylated thio quinazolinones were further sequentially condensed with hydrazine hydrate and different aromatic aldehydes to get the hydrazones, which were studied for QSAR. The synthesized compounds were subjected to a prediction of biological activities. A software application (PASS) was used for this purpose. The relationship between structure and different biological activities was studied and the different derivatives were recommended for the screening of some specific activities like anti-tuberculosic, anti-mycobacterial and HDL cholesterol increasing activities.
A new series of 2-[1-(1,3-diphenyl-1H-pyrazol-4-yl)-meth-(E)-ylidene]-indan-1-one derivatives (5a-l)
have been synthesized through through the Knoevenagel condensation of pyrazole carbaldehydes with
differently substituted 1-indanone derivatives in the presence of base. A high yielding and solvent-free
method was developed for the synthesis of hydrazones from acetophenones under microwave irradiation
in a very short reaction time. Structures of the newly synthesized compounds were affirmed by IR, 1H
& 13C NMR and mass spectroscopic analysis. The confirmed structures were screened for their
antibacterial potency against S. aureus and E. coli bacterial strains. Among the series, compounds 5b,
5c and 5f were evoked as potent antibacterial agents
In the present work,s-alkylated derivatives of thio-quinazolinone were obtained using Methyl 2-chloro propionate via a solvent-free microwave-assisted method. The alkylated thio quinazolinones were further sequentially condensed with hydrazine hydrate and different aromatic aldehydes to get the hydrazides, which were studied for QSAR. The synthesized compounds were subjected to a prediction of biological activities. A software application (PASS) was used for this purpose. . The relationship between structure and different biological activities was studied and the different derivatives were recommended for the screening of some specific activities like anti-tuberculosic, anti-mycobacterial & HDL cholesterol increasing activities.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.