Deep-seated tumors of the liver, brain, and other organ
systems
often recur after initial surgical, chemotherapeutic, radiation, or
focal treatments. Repeating these treatments is often invasive and
traumatic. We propose an iron oxide nanoparticle (IONP)-enhanced precipitating
hydrophobic injectable liquid (PHIL, MicroVention inc.) embolic as
a localized dual treatment implant for nutrient deprivation and multiple
repeatable thermal ablation. Following a single injection, multiple
thermal treatments can be repeated as needed, based on monitoring
of tumor growth/recurrence. Herein we show the ability to create an
injectable stable PHIL-IONP solution, monitor deposition of the PHIL-IONP
precipitate dispersion by μCT, and gauge the IONP distribution
within the embolic by magnetic resonance imaging. Once precipitated,
the implant could be heated to reach therapeutic temperatures >8
°C
for thermal ablation (clinical temperature of ∼45 °C),
in a model disk and a 3D tumor bed model. Heat output was not affected
by physiological conditions, multiple heating sessions, or heating
at intervals over a 1 month duration. Further, in ex vivo mice hind-limb
tumors, we could noninvasively heat the embolic to an “ablative”
temperature elevation of 17 °C (clinically 54 °C) in the
first 5 min and maintain the temperature rise over +8 °C (clinically
a temperature of 45 °C) for longer than 15 min.
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