An efficient, metal/alkali-cyanide free approach for the synthesis of α‐iminonitriles via kinetically controlled, base-mediated and 1,3-diketone-catalyzed reaction is reported. The preparation of target compounds was realized by condensation of substituted...
Several lamellarin alkaloids type III and analogues were synthesized using Barton–Zard and three-component reactions to construct the central pyrrole core.
Polysubstituted pyrrolidines/dihydropyrroles and the corresponding pyrrole derivatives were synthesized via three‐component/pseudo four‐component reaction of chalcone, benzylamine and benzaldehyde, and followed by DDQ oxidation. When exposed to UV light under aerobic conditions, the prepared pyrrole derivatives were found to be light‐sensitive and undergo oxidative ring‐opening reaction to yield the corresponding enamides.
A series of biscoumarin-fused 2,6,9trioxabicyclo[3.3.1]nona-3,7-dienes were synthesized from base-mediated coupling of 4-hydroxycoumarins with benzoyl cyanides and followed by treating with pyridine and thionyl chloride. The mechanism of this reaction was proposed to involve the formation of (E)-2-(2,4-dioxochroman-3-ylidene)-2-phenylacetonitrile as a key intermediate, which could further react with 2-(2,4-dioxochroman-3-yl)-2-hydroxy-2-phenylacetonitrile to yield biscoumarin-fused trioxabicycles.
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