A significant formation of 8-hydroxydeoxyguanosine (8-OHdG) was observed in photoirradiation of “photo-Fenton reagent” (1) with calf thymus DNA in maximum yield of 1.1%. The ten-fold enhancement of the formation of 8-OHdG compared to the control level was observed in photoirradiation of L5178Y cells with 1. The 8-OHdG formation well corresponds to the site specific DNA-cleaving activity of 1 upon photoirradiation.
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