Since Sr0.6Ba0.4Nb2O6 (SBN) is ferroelectric with a tungsten–bronze structure, numerous needlelike ferroelectric domains appear in a SBN single crystal when it is cooled through its transition temperature in the absence of a poling field. If the domains were illuminated by 1.06 μm radiation from a Nd:YAG laser, second-harmonic diffuse light was generated from these domains. This interesting effect, which can clearly be seen with the naked eye, will be used to generate all the primary colors using suitable lasers.

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Oxazolomycinwas isolated and identified from Streptomyces sp. KBFP-2025as an inhibitor against crown gall formation by using a potato tuber disk assay system. This compoundinhibited the early step of crown gall formation, owing to antibacterial activity selectively against Agrobacterium However, very little information is available concerning the early events leading to tumor formation. In order to study further the mechanism for tumor induction, it is necessary to develop a chemical probe that will help exploring the early steps in tumor formation. We have searched for compounds effective in the crown gall formation with the aid of a potato tuber disk assay system from cultures of mi-

Loeys-Dietz Syndrome (LDS) is an autosomal dominant aortic aneurysm syndrome with multisystem involvement, caused by heterozygous mutations of transforming growth factor beta receptor type 1 (TGFBR1) or type 2 (TGFBR2) genes. We report on a neonate with the disorder caused by a known TGFBR2 mutation, who developed neonatal-onset progressive dilation of the aortic valve and aneurysms of the aortic root and main pulmonary artery (PA) associated with a large left-to-right shunt via a ventricular septal defect (VSD) and an atrial septal defect. He also had skeletal features (flexion contractures of the fingers, talipes equinovarus, a cleft palate, and joint laxity), mild facial dysmorphisms, and developmental delay. The dilation and aneurysms progressed after PA banding at age 12 days; and the patient received an intracardiac repair of the defects and PA plasty at age 42 days, followed by no further progression of the dilation and the aneurysms. Neonates with generalized hypotonia, a cleft palate, inguinal herniae, musculoskeletal features such as camptodactyly and talipes equinovarus, and a cardiac murmur should be suspected to have LDS, and extensive cardiovascular evaluation and testing of TGFBR1 and TGFBR2 are recommended. LDS patients with cardiac defects that lead to a large left-to-right shunt and congestive heart failure such as VSD should be considered for intracardiac repair even in early infancy.