M. globosa in its mycelial phase was the main etiological agent, but as normal flora from the back of healthy subjects, it was found in significantly less number (P = 0.01), suggesting that the higher pathogenicity of M. globosa in terms of enzymatic endowment, might be the cause of its predominance in PV lesions.
Background: Pseudomonas aeruginosa is an opportunistic pathogen which causes most of the chronic infection in humans. This study was undertaken to determine the prevalence rate of Pseudomonas aeruginosa that is isolated from various clinical specimens along with its antibiotic susceptibility pattern.Methods: This descriptive cross sectional study was conducted in Kathmandu Medical College and Teaching Hospital (KMCTH) from February to May 2018. Pseudomonas aeruginosa isolated from various clinical specimens were processed in clinical laboratory, Department of Microbiology, KMCTH. Isolation, identification and sensitivity of Pseudomonas aeruginosa to antibiotics were measured.Results: A total of 7527 samples were been processed of which 46 isolates of Pseudomonas aeruginosa were obtained. Pseudomonas aeruginosa was isolated mainly from Pus, Wound swab, Sputum and Tracheal aspirate. Here 63.04% Pseudomonas aeruginosa isolates were resistant to Ceftazidime, 65.21% to Cefixime, 56.52% to Ceftriaxone and Cefotaxime followed by 56.52% to Piperacillin. Furthermore, the current study reveals antibiotics like Imipenem, Meropenem, Piperacillin/Tazobactam, Ciprofloxacin, Gentamicin, Amikacin and Tobramycin were found to be good choice for the treatment of infection caused by this organism.Conclusions: Continuous monitoring of antibiotic susceptibility pattern of Pseudomonas aeruginosa is essential and rational treatment regimens prescription by the clinicians is required to limit the spread of antimicrobial resistance.Keywords: Antibiotic resistance; clinical isolates; Pseudomonas aeruginosa.
The present trial was designed to discover whether the administration of vitamin C ameliorated post-suxamethonium pains. The series consisted of 240 patients undergoing oesophagoscopy, direct laryngoscopy and bronchoscopy. All patients were ambulatory two to three hours after anaesthesia. These patients were selected for the study because ChurchillDavidson', Burtles & Tunstall2 and others, have shown that the incidence of post-suxamethonium muscle pains and stiffness is higher in patients who undergo minor procedures and are ambulatory in the early post-operative period.Patients under the age of 55 years were included in the study. No other selection was done and they were randomly allocated to groups with and without vitamin C (table 1). Table 2 shows the average age and range in each group and also the sex ratio; table 3 shows the number of oesophagoscopies, bronchoscopies and direct laryngoscopies in each series.Patients in the group to whom vitamin C was given were asked to chew a 5OOmg tablet of vitamin C twice a day on the day previous to the procedure, on the day of the procedure and the day following the procedure. The subjects were not given any idea why these tablets were given and took
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