We
have reported an efficient and metal-free method for the construction
of α-diarylmethine imino sulfanone using acid-catalyzed 1,6-conjugate
addition of sulfoximines on para-quinine methides
(p-QMs). This method showed broad functional group
tolerance and a wide range of substrate scope with good to excellent
yield. The excellent protocol exhibits mild reaction conditions with
high atom economy. The practicability of the present method was supported
by a Gram-scale reaction.
The
highly regioselective synthesis of substituted hemiaminal via addition of ethers to quinone imine ketals (QIKs) has
been developed under metal-free conditions. In the presence of tetrabutylammonium
chloride and potassium persulfate (K2S2O8), QIKs couple efficiently with cyclic and acyclic ethers
to give hemiaminals. This strategy offers an easy access to substituted
hemiaminal ethers with high functional group tolerance in good to
excellent yields.
An efficient method for metal-free C–C bond formation between p-quinone methides (p-QMs) and cyclic ethers via a radical pathway to afford substituted diarylmethanes and triarylmethanes or to effect the α-alkylation of the cyclic ethers has been developed.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.