o-Aminoaryl ketones underwent smooth condensation with a variety of α-methylene ketones in the presence of NaHSO 4 .silica gel as a solid acid catalyst to afford 1,2,3-trisubstituted quinolines in excellent yields. The reusability of the catalyst has made the protocol simple, cost-effective and environmentally benign.
Nitriles Q 0520Lithium Tetrafluoroborate-Catalyzed Solventless Synthesis of α-Aminonitriles.-A highly efficient and solvent-free protocol for the synthesis of a wide variety of α-aminonitriles (16 examples) via a three-component reaction of carbonyl compounds with amines and trimethylsilyl cyanide is reported. -(DESAI*, U. V.; MITRAGOTRI, S. D.; THOPATE, T. S.; PORE, D. M.; WADGAONKAR, P. P.; Monatsh. Chem. 138 (2007) 8, 759-762; Dep. Chem., Shivaji Univ., Kolhapur 416 004, India; Eng.) -D. Singer 47-081
Dess-Martin periodinane has been demonstrated for the first time to be an efficient reagent in metal -free oxidation of α-hydroxyphosphonates to α-ketophosphonates under ambient conditions. Acquiescent reaction conditions and a simple isolation procedure are the noteworthy features of the developed protocol.
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