With the outbreak of COVID-19 pandemic, millions of health care workers all across the globe have been working as frontline warriors, in the screening and treatment of patients. 1 As a part of the protective measures, 1 the health care workers are using personal protective equipments (cap, goggles, face shield, surgical mask, gown and gloves), hand sanitizers, and prophylactic drugs like hydroxychloroquine. 2 These measures have been related to the development of certain cutaneousmanifestations. 3
Hydroxychloroquine is the β-hydroxylated analogue of chloroquine which has garnered unprecedented attention as a potential drug for COVID-19, following preliminary reports on its in vitro activity against the virus. Hydroxychloroquine (half-maximal effective concentration [EC50] = 0.72 μM) was found to be more potent than chloroquine (EC50 = 5.47 μM) in vitro against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). 1 By contrast, Liu et al found a lower EC50 for hydroxychloroquine with a similar 50% cytotoxic concentration for both the drugs. 2 A randomized controlled trial from China evaluating hydroxychloroquine 400 mg/day (200 mg BD) from day 1 to 5 for mild COVID-19, reported faster resolution of cough and fever in the hydroxychloroquine arm. 3 The largest observational study of Million et al, with a sample size of 1061 patients, demonstrated good virological and clinical outcomes with hydroxychloroquine therapy. 4 An observational prospective study in 334 health care workers at AIIMS New Delhi, out of which 248 took hydroxychloroquine prophylaxis (median 6 weeks of follow-up) also showed lower incidence of SARS-CoV-2 infection in those taking it. 5 Based on the EC50 values, therapeutic dose of hydroxychloroquine can be calculated. A physiologically based pharmacokinetic modeling study recommended a loading dose of hydroxychloroquine 400 mg PO BD, followed by 200 mg BD for 4 days for the treatment of COVID-19. 1 Nonetheless, this dosing regimen should be interpreted with caution since a 95% confidence interval for the estimate of the EC50 was not provided. The Indian Council of Medical Research has recommended chemoprophylaxis with hydroxychloroquine (400 mg twice on day 1, and then 400 mg once a week thereafter) for asymptomatic frontline workers and household contacts of confirmed cases. 5 The dosing recommendations in the special population, such as pregnant women, obese
Sexually transmitted infections (STI) constitute a major share of the diseases encountered by physicians. Although science has made considerable progress in terms of diagnosing and treating such infections, development of effective and safe vaccines is still needed. Syphilis, viral warts, gonorrhoea, genital herpes, chlamydia and trichomoniasis are the most common infections that are transmitted sexually. In this review, we have attempted to summarize the current status, lacunae and avenues for future research, with reference to the development of STI vaccines.
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The recent development in the institutional ranking by various magazines, private organizations, and government bodies has brought more importance to record management of research publication and research activity (Sunil, 2019). Libraries being the storehouse of knowledge, librarians own the responsibility of managing records about the institute intellectual output and provide data to meet the requirement by assessment, accreditation, survey, and decision-makers. This paper attempts to introduce some of the Research Information Management System (RIMS) tools available in the Open-Source platform to the librarian community. Further, this work discusses certain features that are identified as core or hygiene in RIMS.
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