IntroductionThe hedgehog (Hh) family of proteins [1] is important in many patterning events in the developing embryo, for instance in determining digit position [2] and the development of the nervous system [3]. Hh signal transduction is highly unusual and some of its pathway components act in a rather unique manner [1]. As shown in Fig. 1A

These data suggest that TF/FVIIa activity contributes to the activation of coagulation during E. coli peritonitis but does not play a role in the inflammatory response or antibacterial host defense.

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Overall, the beneficial or harmful effects of activated coagulation and fibrin formation for organ pathology and recovery from DIC remain to be explored. This may be a critical element in the assessment of ischemia-reperfusion effects of specific anticoagulant therapy.