Background In recent years, data-driven medicine has gained increasing importance in terms of diagnosis, treatment, and research due to the exponential growth of health care data. However, data protection regulations prohibit data centralisation for analysis purposes because of potential privacy risks like the accidental disclosure of data to third parties. Therefore, alternative data usage policies, which comply with present privacy guidelines, are of particular interest. Objective We aim to enable analyses on sensitive patient data by simultaneously complying with local data protection regulations using an approach called the Personal Health Train (PHT), which is a paradigm that utilises distributed analytics (DA) methods. The main principle of the PHT is that the analytical task is brought to the data provider and the data instances remain in their original location. Methods In this work, we present our implementation of the PHT paradigm, which preserves the sovereignty and autonomy of the data providers and operates with a limited number of communication channels. We further conduct a DA use case on data stored in three different and distributed data providers. Results We show that our infrastructure enables the training of data models based on distributed data sources. Conclusion Our work presents the capabilities of DA infrastructures in the health care sector, which lower the regulatory obstacles of sharing patient data. We further demonstrate its ability to fuel medical science by making distributed data sets available for scientists or health care practitioners.

The constant upward movement of data-driven medicine as a valuable option to enhance daily clinical practice has brought new challenges for data analysts to get access to valuable but sensitive data due to privacy considerations. One solution for most of these challenges are Distributed Analytics (DA) infrastructures, which are technologies fostering collaborations between healthcare institutions by establishing a privacy-preserving network for data sharing. However, in order to participate in such a network, a lot of technical and administrative prerequisites have to be made, which could pose bottlenecks and new obstacles for non-technical personnel during their deployment. We have identified three major problems in the current state-of-the-art. Namely, the missing compliance with FAIR data principles, the automation of processes, and the installation. In this work, we present a seamless on-boarding workflow based on a DA reference architecture for data sharing institutions to address these problems. The on-boarding service manages all technical configurations and necessities to reduce the deployment time. Our aim is to use well-established and conventional technologies to gain acceptance through enhanced ease of use. We evaluate our development with six institutions across Germany by conducting a DA study with open-source breast cancer data, which represents the second contribution of this work. We find that our on-boarding solution lowers technical barriers and efficiently deploys all necessary components and is, therefore, indeed an enabler for collaborative data sharing.

Skin cancer has become the most common cancer type. Research has applied image processing and analysis tools to support and improve the diagnose process. Conventional procedures usually centralise data from various data sources to a single location and execute the analysis tasks on central servers. However, centralisation of medical data does not often comply with local data protection regulations due to its sensitive nature and the loss of sovereignty if data providers allow unlimited access to the data. The Personal Health Train (PHT) is a Distributed Analytics (DA) infrastructure bringing the algorithms to the data instead of vice versa. By following this paradigm shift, it proposes a solution for persistent privacy- related challenges. In this work, we present a feasibility study, which demonstrates the capability of the PHT to perform statistical analyses and Machine Learning on skin lesion data distributed among three Germany-wide data providers.

In recent years, implementations enabling Distributed Analytics (DA) have gained considerable attention due to their ability to perform complex analysis tasks on decentralised data by bringing the analysis to the data. These concepts propose privacy-enhancing alternatives to data centralisation approaches, which have restricted applicability in case of sensitive data due to ethical, legal or social aspects. Nevertheless, the immanent problem of DA-enabling architectures is the black-box-alike behaviour of the highly distributed components originating from the lack of semantically enriched descriptions, particularly the absence of basic metadata for datasets or analysis tasks. To approach the mentioned problems, we propose a metadata schema for DA infrastructures, which provides a vocabulary to enrich the involved entities with descriptive semantics. We initially perform a requirement analysis with domain experts to reveal necessary metadata items, which represents the foundation of our schema. Afterwards, we transform the obtained domain expert knowledge into user stories and derive the most significant semantic content. In the final step, we enable machine-readability via RDF(S) and SHACL serialisations. We deploy our schema in a proof-of-concept monitoring dashboard to validate its contribution to the transparency of DA architectures. Additionally, we evaluate the schema’s compliance with the FAIR principles. The evaluation shows that the schema succeeds in increasing transparency while being compliant with most of the FAIR principles. Because a common metadata model is critical for enhancing the compatibility between multiple DA infrastructures, our work lowers data access and analysis barriers. It represents an initial and infrastructure-independent foundation for the FAIRification of DA and the underlying scientific data management.

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