A specific activation of microglia was only found in patients in whom the PT was affected by the stroke and only caudal (anterograde) to the lesion; no activation was found in the retrograde direction or in those patients in whom the PT was not affected. These findings were independent of infarct size and may represent changes secondary to early Wallerian degeneration.
PREFACE
Structure of ThesisThis thesis is formatted into chapters. The first chapter includes a background to the subject of structure, function and morphology of the corticospinal tract as well as the method of transcranial magnetic stimulation. This chapter also delineates the rationale, objectives and hypothesis for the presented study. The second chapter describes the methods and procedures used for the collection and analysis of data pertaining to this study. The third chapter presents the results of this research. The fourth and final chapter includes a discussion, conclusion as well as future recommendations on the subject of dose-response curves as predictors of corticospinal tract integrity.
Contribution of Authors
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