A passive, continuous and size-dependent focusing technique enabled by “inertial microfluidics”, which takes advantage of hydrodynamic forces, is implemented in this study to focus microparticles. The objective is to analyse the decoupling effects of inertial forces and Dean drag forces on microparticles of different sizes in curvilinear microchannels with inner radius of 800 μm and curvature angle of 280°, which have not been considered in the literature related to inertial microfluidics. This fundamental approach gives insight into the underlying physics of particle dynamics and offers continuous, high-throughput, label-free and parallelizable size-based particle separation. Our design allows the same footprint to be occupied as straight channels, which makes parallelization possible with optical detection integration. This feature is also useful for ultrahigh-throughput applications such as flow cytometers with the advantages of reduced cost and size. The focusing behaviour of 20, 15 and 10 μm fluorescent polystyrene microparticles was examined for different channel Reynolds numbers. Lateral and vertical particle migrations and the equilibrium positions of these particles were investigated in detail, which may lead to the design of novel microfluidic devices with high efficiency and high throughput for particle separation, rapid detection and diagnosis of circulating tumour cells with reduced cost.
The necessity of microscale mixing processes has been tremendously increasing in most of the microsize chemical and biochemical devices during recent years, particularly in the design of lab-on-a-chip and micro-total analysis systems. Different approaches were implemented in the available micromixers in the literature for improving the mixing performance.Due to the absence of any external source, mixing by utilizing passive mixing techniques is more economical. In curvilinear microchannels, which offer effective passive mixing, chaotic advection results in continuous radial perforation of inter-diffusion layer between the fluid streams due to the transverse secondary flows. In this dissertation, the effects of Dean vortices and secondary flows were investigated in asymmetrical polydimethylsiloxane curvilinear rectangular microchannels, which were fabricated by onestep lithography process and had repeated S-shape patterns with a curvature of 280° along the channel.Moreover, the effect of asymmetry was assessed by comparing the mixing results with symmetrical microchannels. Mixing performance was analyzed by using NaOH and phenolphthalein solutions as mixing fluids, which entered from the channel inlets. According to the results, the significant effects of stretching and contracting motion of Dean vortices revealed themselves above a certain Dean number value, thereby making the asymmetrical microchannel outperform the symmetrical channel in the mixing performance. Below this threshold, the symmetrical microchannel was observed to be superior to the asymmetrical microchannel.
This study experimentally and numerically investigates the effects of the nozzle/needle distance (clearance) and supply pressure on single phase compressible gas flow in a micro orifice with needle restriction, which play important roles in many engineering applications such as cryogenic cooling and MEMS (microelectromechanical systems) device cooling. Nitrogen was used as the working fluid at supply pressures ranging from 10 to 50 bars, while the conical needle draft angle was 15°. The nozzle/needle distance (clearance) was changed from 100 µm to 500 µm. From the experimental point of view, the load provided by the working fluid over the needle was measured by a load sensor. For the numerical analysis, six turbulence models and three wall treatments were considered in numerical simulations. The effect of micro restriction on high-pressure micro-gas flows was further assessed by numerical modeling. It is evident from the results that the utilized turbulence model has a considerable effect on the computed results. The k–ε standard and Spalart–Allmaras models were found to be not suitable for modeling micro-scale gas flows with restriction. On the other hand, the k–ε realizable and k–ω SST models exhibit the best performance in predicting the results.
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