Background: Hypertension and dyslipidemia are major risk factors for cardiovascular disease (CVD) and a leading cause of morbidity and mortality in both developed and developing countries. The prevalence of hypertension is projected to increase globally, especially in the developing countries.
Background: Hypothyroidism is a common endocrinal disorder caused by insufcient production of thyroid hormones. Subclinical hypothyroidism (SCH) can be dened as a state of high serum thyroid stimulating hormone (TSH) levels (less than 10µIU/ml) with normal serum free thyroxine (fT ) and triiodothyronine (fT ) levels in 4 3 the presence or absence of symptoms. Creatinine is a chemical waste product that is produced by muscle metabolism. Creatinine is produced from creatine, a molecule of major importance for energy production in muscles. Thyroid dysfunction can affect renal physiology and development, and on the other hand, kidney disorders can inuence thyroid function. This study was aimed to nd out the status of serum fT , fT ,TSH and serum creatinine levels in subclinical hypothyroid cases and 3 4 healthy controls. Materials and Methods: The present study is descriptive case control study, was conducted in the Department of Biochemistry, J.L.N. Medical College and Associated group of Hospitals, Ajmer (Raj.). 130 cases of subclinical hypothyroidism attending Medical OPD of J.L.N. Hospitals were included and 50 age-sex matched euthyroid controls were selected. Results: The mean serum creatinine levels were found to be signicantly high in subclinical hypothyroid cases(0.99 + 0.19 mg%) as compared to healthy controls (0.75 + 0.15 mg%), (p<0.0001). Conclusion: Serum creatinine can be used as a biomarker for early detection of subclinical hypothyroidism in general population to prevent the morbidity and mortality which are associated with hypothyroidism. Early diagnosis and intervention of subclinical hypothyroid and their cluster of risk factor can prevent the renal dysfunction.
The aim of the study was to measure serum levels of Resistin in impaired glucose tolerance (IGT) and Newly diagnosed type 2 diabetics (NDT2D) and compare with healthy control subjects. In this study 61 IGT, 61 NDT2D and 61 healthy subjects (age and gender matched) were enrolled. Insulin and Resistin were assessed. Serum Resistin levels were higher in IGT and NDT2D subjects compared with healthy controls (9.16±3.06ng/ml, 14.5±5.31ng/ml vs 5.11±1.56ng/ml, respectively, p<0.0001). Increased serum Resistin levels in IGT and NDT2D over healthy subjects. Key words: Resistin, IGT, NDT2D
Background: Hypertension is recognized as the most common cause of cardiovascular disorder and a leading cause of morbidity and mortality in both developed and developing countries. Gamma-glutamyl transpeptidase is serum transferase enzyme synthesised by liver. It is commonly used in clinical practice to monitor liver function, hepato-biliary disorders and as a marker of alcohol intake. It has been proposed that gamma glutamyl transpeptidase is a potent preclinical marker of atherosclerosis. Hyperhomocysteinemia (HHcy) has been regarded as a new risk factor related to hypertension. Our study was aimed to find out the status of serum gamma glutamyl transpeptidase and homocysteine in hypertensive and normotensive subjects & Correlation of serum GGT with serum homocysteine in hypertensive subjects. Materials and methods: The present study was conducted on 100 patients with essential hypertension who attended the medical OPD of Jawahar Lal Nehru Medical College and Associated Group of Hospital, Ajmer. The results of patients were compared with 50 normotensive subjects. Anthropometric parameters and biochemical estimation were performed after taking approval from Ethical Committee. The Serum GGT was measured by colorimetric kinetic assay and Serum Homocysteine was measured by ELISA technique. Results: The mean serum level of GGT was elevated in hypertensive subjects as compared to normotensive subjects (controls) and was statistically significant (P<0.001). The mean serum level of Homocysteine was elevated in hypertensive subjects as compared to normotensive subjects and was highly significant (P<0.0001).The present study has also shown a positive correlation (r=0.74) between serum GGT & serum homocysteine in hypertensive subjects. Conclusion: The present study shows that the level of both, serum GGT and serum homocysteine is raised in young adult patients with essential hypertension and has also shown a positive correlation between serum GGT & serum homocysteine in these subjects. Thus the elevated GGT and Homocysteine in young adults may contribute to their susceptibility to hypertension and provide an additional evidence of novel role of GGT and Homocysteine in cardiovascular risk evaluation. This study was limited and needs to be further worked upon.
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