Novel Racemic Tetrahydrocurcuminoid Dihydropyrimidinone Analogues as Potent Acetylcholinesterase Inhibitors. -A variety of the title pyrimidinone derivatives (IV) (12 examples) are synthesized utilizing a CuSO4-catalyzed multicomponent Biginelli reaction. Compound (IVd) possesses a highly effective inhibitory activity of acetylcholinesterase, and is slightly more potent than the reference compound galanthamine. -(ARUNKHAMKAEW, S.; ATHIPORNCHAI, A.; APIRATIKUL, N.; SUKSAMRARN, A.; AJAVAKOM*, V.; Bioorg. Med. Chem. Lett. 23 (2013) 10, 2880-2882, http://dx.
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