Background: The expression of Sialyl-Tn (STn) has been associated with different mechanisms of cancer.Several studies using histological tissue samples from different types of cancer showed differences in the STn expression patterns, but few studies have explored the association between STn expression and decreased overall survival. Therefore, a comprehensive analysis of the clinical significance of STn in cancer patients was performed.Methods: A systematic review and meta-analysis were done of scientific articles published and available from different sources, including MEDLINE/PubMed, Web of Science, Cochrane Library and LILACS.Odds ratio (OR) was represented by the number of deaths during follow-up in positive-STn versus negative-STn patients. OR from each study was pooled and the results were presented in a forest plot.Results: Eleven articles were included in the systematic meta-analysis. The estimated OR of 3.26 (95% CI: 2.12-5.02) was obtained. Furthermore, subgroups studies of gastric cancer showed an OR of 3.74 (95% CI: 2.47-5.66) and other cancer types reported an OR of 2.92 (95% CI: 1.16-7.32).Conclusions: This study showed that survival time was significantly longer in patients with negative-STn tumors than in those with positive results.
Background: During the nutritional assessment of elderly patients, it is important to take into account the physical changes of aging. It is well known that hospitalized patients are more vulnerable to develop malnutrition. The Mini Nutritional Assessment (MNA) questionnaire allows the adequate classification of the nutritional status of these patients. In Yucatan, there are no reports on the nutritional status among this group of patients. Therefore, the aim of this study was to assess nutritional status of elderly patients in this referral hospital using the MNA questionnaire. Methods: A total of 100 hospitalized patients older than 60 years were evaluated from February to May 2019. The MNA questionnaire was applied, anthropometric measurements were collected and laboratory tests were done. Results: 55% were female and 45% were male. According to MNA, 53% of the population was classified at risk of malnutrition, 31% with malnutrition and 26% as having a normal nutritional status. Conclusions: The evaluation of the nutritional status among elderly hospitalized patients using the MNA showed that half of the population were at risk of malnutrition. Early recognition of malnutrition and adequate intervention among hospitalized patients can prevent later complications in the treatment and convalescence period.
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