Synthesis of Novel Substituted Pyridines as Inhibitors of EndothelinConverting Enzyme-1 (ECE-1).-A series of heteroaryl substituted pyridine carboxylic acids is prepared and evaluated as inhibitors of ECE-1. These compounds are prepared by Pd-catalyzed cross couplings of halogenated pyridines with heteroaryl organometallics. The thiazole-4-yl moiety is found to be the most active one. -(MASSA, M. A.; PATT, W. C.; AHN, K.; SISNEROS, A. M.; HERMAN, S. B.; DOHERTY, A.; Bioorg. Med. Chem.
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