Rheumatoid arthritis is a common autoimmune disease. Malignancy is a serious complication of rheumatoid arthritis and its treatment. In this article, we discuss a 61-year-old woman who is a known case of Rheumatoid arthritis and secondary Sjögren's syndrome treated with disease-modifying antirheumatoid drugs and multiple lines of biological therapies. She was found to have recto-sigmoid cancer, disseminated tuberculosis infection, and acute lymphoid leukemia at different intervals of treatment. Therefore, it is advisable to initiate appropriate screening programs that target high-risk people for malignancy.
This is a case report of a 31-year-old lady who is known to have ulcerative colitis for 15 years and was on mesalazine. She presented with periorbital swelling, sinusitis, epistaxis, and was found to have positive antineutrophil cytoplasmic antibody and anti-proteinase-3 of a high titer. Biopsy from the maxillary sinus showed chronic non-specific inflammation and biopsy from the periorbital fat revealed inflammation and granulomatous changes. She had no other organ involvement. She was diagnosed with a limited form of granumatosis and polyangiitis and treated with methotrexate and prednisolone. The symptoms disappeared after treatment.
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