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Background: preeclampsia is characterized by endothelial dysfunction with vasoconstriction due to cell adhesion molecules or mediators released by defective placentation. Soluble platelet selectin, one of the cell adhesion molecules, is elevated in many inflammatory conditions including preeclampsia.Objective: To investigate if soluble platelet-selectin levels can be used as a marker for adverse outcomes in pregnancy complicated with sever preeclampsiaPatients and methods:This study involved 115 pregnant women in their third trimester of pregnancy; divided into Group A: involves 25 pregnant women with preeclampsia complicated by intrauterine growth restriction.Group B: involves 35 pregnant women with preeclampsia without intrauterine growth restriction.Control group: involve 55 pregnant women with normal blood pressure and normal fetal growth .The data were conducted from patients by special questionnaire, this involve name, age, parity, examination included vital signs, abdominal, obstetrical examination and investigations including :Liver function test, Renal function test, Complete blood picture and maternal serum levels of soluble platelet selectin was measured by enzyme-linked immunosorbent assay ,albumin in urine and serial obstetrical ultrasound scan to confirm the diagnosis of intrauterine growth retardation and Doppler study to determine fetuses at risk .Results: this study revealed a significantly higher concentration of soluble platelet selectin levels in serumofpreeclamptic women with and without intrauterine growth retardation versus normotensive and normal fetal growth. The maternal serum levels of sP-selectin in preeclampsia without intrauterine growth restriction were significantly higher than preeclampsia complicated by intrauterine growth restriction .Sensitivity was 91.7% and specificity 100% at cut off value 6.975 ng/ml of maternal soluble platelet _selectin for prediction of adverse pregnancy outcome .Conclusion: soluble platelet -selectin levels have a positive significant correlation with the severity of preeclampsia, so it can beconsidered as a marker for its severity and can be used as a predictor for adverse outcomes as itsnegatively correlated with these complications

Background:Atenolol is one of b–adrenergic receptor blocking agent, that is widely and commonly used in the treatment of hypertension, its lowering high blood pressure effectively but, it has many side effects on different body organs and tissues, some of them are serious.Objectives:To prove the association between Atenolol and heart failure through studying the effects of this drug on the levels of some parameters that are present in the blood including: total serum cholesterol, serum triglyceride and aspartate transaminase enzyme in early and long term usage of this drug by hypertensive patients, these parameters are chosen because they give an early indication about future development of cardiovascular disease.Methods:Case comparative study was conducted in Al-Yarmouk teaching hospital for one year and seven months on (40) hypertensive patients, they were dividedinto (2) groups according to the duration of the treatment:Group І: (20) patients with mean age (56 + 8) years .They used the drug for a period from (1-3) years.Group II: also (20) patients with mean age (55+ 8) years used the drug for (4- 10) years.Both groups were with the same number of sex and nearly the same age, venous blood samples are taken from each patients and levels of total serum cholesterol, serum triglyceride (S.TG), and Aspartate transaminase (AST) were estimated and compared between the (2) groups.Results:The mean of total serum cholesterol was significantly higher in group II than in group I (p<0.05) , the mean of S.TG was significantly higher in group II (p<0.05).Conclusion:Atenolol causes increase levels of total serum cholesterol, S.TG and AST and this increase is directly proportion to the duration of the drug usage and as they are affect on cardiovascular system and causing cardiovascular diseases by their high levels , so Atenolol has significant correlation with the developmentof cardiovascular diseases especially heart failure.