Vitamin D (Vit D) is a prohormone that can be activated during a sequential hydroxylation done by two major mitochondrial cytochrome P450 liver and renal enzymes. Vit D-dependent rickets type 1 (VDDR1) is a rare autosomal recessive hereditary disorder resulting from defective renal 1α-OHase presenting with severe rickets, hypocalcemia, and secondary hyperparathyroidism. Although homozygous Vit D hydroxylation deficient patients develop severe rickets symptom and signs before the age of 12 months, heterozygous types have minor symptoms and are extremely rare presenting as late as 14 years after birthday. Here we present a suspicious case of VDDR1 at 21 years old of age with mild symptoms and signs.
Introduction: Frotteuristic sexual interest is a rare psychiatric disorder characterized by at least six months of recurrent and intense sexual arousal from touching or rubbing against a non-consenting person, usually in a crowd. Case Presentation: A six-year-old boy was referred to the psychiatrist while accompanied by his mother and grandmother with the complaint of excessively rubbing his genitalia many times a day against his female family members' bodies, primarily their buttocks. Conclusions: Experts are advised to focus on diverse sexual history dimensions, especially uncontrollable masturbation behaviors, that can predict sexual interests. Although frotteurism is a rare psychiatric disorder, and although this case is atypical given the early childhood presentation of abnormal sexual behavior carried out secretly and not in a crowd, it is clear that frotteurism is the appropriate diagnosis after ruling out other more common disorders.
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