Background
The combination of sofosbuvir and daclatasvir has shown preliminary efficacy for hospitalized patients with COVID-19 in four open-label studies with small sample sizes. This larger trial aimed to assess if the addition of sofosbuvir/daclatasvir to standard care improved clinical outcomes in hospitalized patients with COVID-19.
Methods
This was a placebo-controlled, double-blind, randomized clinical trial in adults hospitalized with COVID-19 at 19 hospitals in Iran. Patients were randomized to oral sofosbuvir/daclatasvir 400/60 mg once-daily or placebo in addition to standard of care. Patients were included if they had positive PCR or diagnostic chest CT, O2 saturation <95% and compatible symptoms. The primary outcome was hospital discharge within 10 days of randomization. Secondary outcomes included mortality and time to clinical events. The trial is registered on the Iran Registry of Clinical Trials under IRCT20200624047908N1.
Results
Between July and October 2020, 1083 patients were randomized to either the sofosbuvir/daclatasvir arm (n = 541) or the placebo arm (n = 542). No significant difference was observed in the primary outcome of hospital discharge within 10 days, which was achieved by 415/541 (77%) in the sofosbuvir/daclatasvir arm and 411/542 (76%) in the placebo arm [risk ratio (RR) 1.01, 95% CI 0.95–1.08, P = 0.734]. In-hospital mortality was 60/541 (11%) in the sofosbuvir/daclatasvir arm versus 55/542 (10%) in the placebo arm (RR 1.09, 95% CI 0.77–1.54, P = 0.615). No differences were observed in time to hospital discharge or time to in-hospital mortality.
Conclusions
We observed no significant effect of sofosbuvir/daclatasvir versus placebo on hospital discharge or survival in hospitalized COVID-19 patients.
Introduction:Employee engagement is an important indicator of performance in various organizational positions and leads to increasing the motivation to stay in the organization and job satisfaction. The aim of this study was to investigate the relationship between work-family conflict and employee engagement in female nurses working in intensive care units. Methods: This cross-sectional study was carried out from January 2015 to 2016 in educational hospitals in Bushehr, Iran, on female nurses working in intensive care units. The Thomas Ladahl and Kejner questionnaire was used to measure employee engagement, and the Kamkar and Madani's questionnaire to measure workfamily conflict was used. Data were analyzed using SPSS 16 software via regression and Pearson correlation coefficient. Results: One hundred twenty employee female nurses working in intensive care units were studied. The mean score of work-family conflict was 102 ± 24, and the mean score of female nurse's employee engagement was 34 ± 5. Findings showed a negative significant correlation between age and work history with employee engagement (p = 0.00). Also, there was a negative significant correlation between work-family conflict and employee engagement (p = 0.005). Conclusion: Work-family conflict is a significant predictor of employee engagement, which, by adjusting, can increase the employee engagement in nurses.
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