Introduction Individuals with intellectual disability (ID) have an increased risk of cardiovascular disease and reduced work capacity, which could partly be explained by alterations to autonomic and hemodynamic regulation. The measurement of heart rate and blood pressure during isometric handgrip (HG) exercise, a sympathoexcitatory stimulus, is a noninvasive method to investigate autonomic and hemodynamic alterations. The purpose of this study was to assess alterations to autonomic and associated hemodynamic regulation between individuals with ID and a matched control group during isometric HG exercise. Methods Individuals with ID (n = 13; 31 ± 2 yr, 27.6 ± 7.7 kg·m−2) and without ID (n = 16; 29 ± 7 yr, 24.2 ± 2.8 kg·m−2) performed 2 min of isometric HG exercise at 30% of maximal voluntary contraction (MVC) in the seated position. Blood pressure was averaged for 2 min before, during, and after HG exercise (mean arterial pressure [MAP], systolic blood pressure, and diastolic blood pressure). Heart rate variability, blood pressure variability, and baroreflex sensitivity were calculated from the continuous blood pressure and heart rate recordings. Results Isometric HG elicited a blunted response in systolic blood pressure, diastolic blood pressure, and MAP among individuals with ID compared with individuals without ID, even after controlling for strength (MAP: rest, HG, recovery; ID: 103 ± 7, 108 ± 9, 103 ± 7; without ID: 102 ± 7, 116 ± 10, 104 ± 10 mm Hg; interaction P < 0.05). Individuals with ID also had an attenuated baroreflex sensitivity response to HG exercise compared with individuals without ID (interaction P = 0.041), but these effects were no longer significant after controlling for maximal voluntary contraction. Indices of heart rate variability and blood pressure variability were not different between groups overall or in response to HG exercise (P > 0.05). Conclusions Individuals with ID have a blunted hemodynamic and autonomic response to isometric HG exercise compared with individuals without ID.

Background Improved strategies for stent-based treatment of coronary artery disease at bifurcations requires a greater understanding of artery morphology. Objective We developed a workflow to quantify morphology in the left main coronary (LMCA), left anterior descending (LAD), and left circumflex (LCX) artery bifurcations. Methods Computational models of each bifurcation were created for 55 patients using computed tomography images in 3D segmentation software. Metrics including cross-sectional area, length, eccentricity, taper, curvature, planarity, branching law parameters, and bifurcation angles were assessed using open-sources software and custom applications. Geometric characterization was performed by comparison of means, correlation and linear discriminant analysis (LDA). Results Differences between metrics suggest dedicated or multi-stent approaches should be tailored for each bifurcation. For example, the side branch of the LCX (i.e., obtuse marginal; OM) was longer than that of the LMCA (i.e. LCXprox) and LAD (i.e. first diagonal; D1). Bifurcation metrics for some locations (e.g. LMCA Finet ratio) provide results and confidence intervals agreeing with prior findings, while revised metric values are presented for others (e.g., LAD & LCX). LDA revealed several metrics that differentiate between artery locations (e.g., LMCA vs D1, LMCA vs OM, LADprox vs D1, and LCXprox vs D1). Conclusions These results provide a foundation for elucidating common parameters from healthy coronary arteries and could be leveraged in the future for treating diseased arteries. Collectively the current results may ultimately be used for design iterations that improve outcomes following implantation of future dedicated bifurcation stents.

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Purpose: To assess the agreement of the root mean square of successive R-R interval (RMSSD) values when recorded immediately upon waking to values recorded later in the morning prior to practice, and to determine the associations of the RMSSD recordings with performance outcomes in female rowers. Methods: A total of 31 National Collegiate Athletic Association Division I rowers were monitored for 6 consecutive days. Two seated RMSSD measurements were obtained on at least 3 mornings using a smartphone-based photoplethysmography application. Each 1-minute RMSSD measure was recorded following a 1-minute stabilization period. The first (T1) measurement occurred at the athlete’s home following waking, while the second (T2) transpired upon arrival at the team’s boathouse immediately before practice. From the measures, the RMSSD mean and coefficient of variation were calculated. Two objective performance assessments were conducted on an indoor rowing ergometer on separate days: 2000-m time trial and distance covered in 30 minutes. Interteam rank was determined by the coaches, based on subjective and objective performance markers. Results: The RMSSD mean (intraclass correlation coefficient = .82; 95% CI, .63 to .92) and RMSSD coefficient of variation (intraclass correlation coefficient = .75; 95% CI, .48 to .88) were strongly correlated at T1 and T2, P < .001. The RMSSD mean at T1 and T2 was moderately associated with athlete rank (r = −.55 and r = −.46, respectively), 30-minute distance (r = .40 and r = .41, respectively), and 2000 m at T1 (r = −.37), P < .05. No significant correlations were observed for the RMSSD coefficient of variation. Conclusion: Ultrashort RMSSD measurements taken immediately upon waking show very strong agreement with those taken later in the morning, at the practice facility. Future research should more thoroughly investigate the relationship between specific performance indices and the RMSSD mean and coefficient of variation for female collegiate rowers.