Context: The purpose of this study was to investigate the research framework on the effect of physical activity on cardiovascular markers (C-reactive protein (CRP) and Homocysteine (HCY)), and to conduct an optimal compilation to present better information from previous studies. Evidence Acquisition: In this study, a number of articles were searched in specialized databases and 30 articles were selected based on entry and exit criteria. Then the responses to one bout of aerobic activity and one bout of resistance activity and adaptability with aerobic training and resistance training were studied. Results: Various studies have shown a reverse and significant relationship between regular physical activity and inflammatory indices, and reported that those who are physically more active and have better physical fitness have lower levels of inflammatory indices. Conclusions: The present study showed that regular physical activity has a beneficial effect on the prevention and treatment of coronary artery disease. Regarding the anti-inflammatory effects of physical activity, regular exercise and regular physical activity play an important role in reducing inflammatory indices, and aerobic exercises can be a useful and appropriate strategy for coping with inflammatory and cardiovascular risk factors.
Background: One of the side effects of myocardial infarction is the changes in slow contraction muscle phenotype to fast contraction due to decreased mitochondrial density. Mitochondrial biogenesis with its ability to create new mitochondria and increase mitochondrial density can minimize these complications. NRF-1,2 and Tfam are proteins that affect mitochondrial biogenesis that induces mitochondrial biogenesis by regulating mitochondrial DNA in the nucleus. Therefore, the aim of this study was to investigate the effect of eight weeks of high intensity interval training on expression of NRF-1,2 and Tfam genes in the rats with myocardial infarction.Methods: In this experimental study, which was done experimentally, 12 Wistar male rats with myocardial infarction were divided into two experimental groups (30 minutes on a treadmill on a regular basis and 4 minutes running with a severity of 90-85% VO2max and two minutes of active recovery with 50% -60% VO2max three days a week for eight weeks) and control (without exercise). The expression of NRF-1,2 and Tfam genes was studied as an effective factor in downstream mitochondrial biogenesis. Statistical data were analyzed with independent T test in spss18 (α≥0.05).Results: The results showed that the expression of NRF-1, NRF-2 and Tfam genes increased significantly (in at all P≤0.001).Conclusion: Generally, eight weeks of high intensity interval training increase mitochondrial biogenesis in slow muscle of myocardial infarction rats with effect on NRF-1, NRF-2 and Tfam genes.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.